The Stabilization of S100A9 Structure by Calcium Inhibits the Formation of Amyloid Fibrils

The Stabilization of S100A9 Structure by Calcium Inhibits the Formation of Amyloid Fibrils

The calcium-binding protein S100A9 is recognized as an important component of the brain neuroinflammatory response to the onset and development of neurodegenerative disease. S100A9 is intrinsically amyloidogenic and in vivo co-aggregates with amyloid-β peptide and α-synuclein in Alzheimer’s and Park...

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Main Authors: Ella Sanders, Rebecca Csondor, Darius Šulskis, Ieva Baronaitė, Vytautas Smirnovas, Luckshi Maheswaran, Jack Horrocks, Rory Munro, Christina Georgiadou, Istvan Horvath, Ludmilla A. Morozova-Roche, Philip T. F. Williamson
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
amyloid
S100A9
protein stability
neurodegenerative disease
Alzheimer’s disease
Parkinson’s disease
Online Access:https://www.mdpi.com/1422-0067/24/17/13200

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