Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019
Azithromycin-nonsusceptible Neisseria gonorrhoeae strains are an emerging global public health threat. During 2015–2018, the prevalence of azithromycin-nonsusceptible gonococcal infection increased significantly in Argentina. To investigate the genomic epidemiology and resistance mechanisms of these...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2021-09-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/27/9/20-4843_article |
| _version_ | 1818332310598057984 |
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| author | Ricardo Ariel Gianecini Tomas Poklepovich Daniel Golparian Noelia Cuenca Ezequiel Tuduri Magnus Unemo Josefina Campos Patricia Galarza |
| author_facet | Ricardo Ariel Gianecini Tomas Poklepovich Daniel Golparian Noelia Cuenca Ezequiel Tuduri Magnus Unemo Josefina Campos Patricia Galarza |
| author_sort | Ricardo Ariel Gianecini |
| collection | DOAJ |
| description | Azithromycin-nonsusceptible Neisseria gonorrhoeae strains are an emerging global public health threat. During 2015–2018, the prevalence of azithromycin-nonsusceptible gonococcal infection increased significantly in Argentina. To investigate the genomic epidemiology and resistance mechanisms of these strains, we sequenced 96 nonsusceptible isolates collected in Argentina during 2005–2019. Phylogenomic analysis revealed 2 main clades, which were characterized by a limited geographic distribution, circulating during January 2015–November 2019. These clades included the internationally spreading multilocus sequence types (STs) 1580 and 9363. The ST1580 isolates, which had MICs of 2–4 μg/mL, had mutations in the 23S rRNA. The ST9363 isolates, which had MICs of 2–4 or >256 μg/mL, had mutations in the 23S rRNA, a mosaic mtr locus, or both. Identifying the geographic dissemination and characteristics of these predominant clones will guide public health policies to control the spread of azithromycin-nonsusceptible N. gonorrhoeae in Argentina. |
| first_indexed | 2024-12-13T13:33:43Z |
| format | Article |
| id | doaj.art-dbe732f9f43b4d329a6da95067860080 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-13T13:33:43Z |
| publishDate | 2021-09-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-dbe732f9f43b4d329a6da950678600802022-12-21T23:44:04ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592021-09-012792369237810.3201/eid2709.204843Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019Ricardo Ariel GianeciniTomas PoklepovichDaniel GolparianNoelia CuencaEzequiel TuduriMagnus UnemoJosefina CamposPatricia GalarzaAzithromycin-nonsusceptible Neisseria gonorrhoeae strains are an emerging global public health threat. During 2015–2018, the prevalence of azithromycin-nonsusceptible gonococcal infection increased significantly in Argentina. To investigate the genomic epidemiology and resistance mechanisms of these strains, we sequenced 96 nonsusceptible isolates collected in Argentina during 2005–2019. Phylogenomic analysis revealed 2 main clades, which were characterized by a limited geographic distribution, circulating during January 2015–November 2019. These clades included the internationally spreading multilocus sequence types (STs) 1580 and 9363. The ST1580 isolates, which had MICs of 2–4 μg/mL, had mutations in the 23S rRNA. The ST9363 isolates, which had MICs of 2–4 or >256 μg/mL, had mutations in the 23S rRNA, a mosaic mtr locus, or both. Identifying the geographic dissemination and characteristics of these predominant clones will guide public health policies to control the spread of azithromycin-nonsusceptible N. gonorrhoeae in Argentina.https://wwwnc.cdc.gov/eid/article/27/9/20-4843_articlewhole-genome sequencinggonorrheaazithromycinantimicrobial resistancetreatmentAMR |
| spellingShingle | Ricardo Ariel Gianecini Tomas Poklepovich Daniel Golparian Noelia Cuenca Ezequiel Tuduri Magnus Unemo Josefina Campos Patricia Galarza Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019 Emerging Infectious Diseases whole-genome sequencing gonorrhea azithromycin antimicrobial resistance treatment AMR |
| title | Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019 |
| title_full | Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019 |
| title_fullStr | Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019 |
| title_full_unstemmed | Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019 |
| title_short | Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019 |
| title_sort | genomic epidemiology of azithromycin nonsusceptible neisseria gonorrhoeae argentina 2005 2019 |
| topic | whole-genome sequencing gonorrhea azithromycin antimicrobial resistance treatment AMR |
| url | https://wwwnc.cdc.gov/eid/article/27/9/20-4843_article |
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