Development and characterization of mouse anti-canine PD-L1 monoclonal antibodies and their expression in canine tumors by immunohistochemistry in vitro

Development and characterization of mouse anti-canine PD-L1 monoclonal antibodies and their expression in canine tumors by immunohistochemistry in vitro

AbstractImmune escape is the hallmark of carcinogenesis. This widely known mechanism is the overexpression of immune checkpoint ligands, such as programmed cell death protein 1 and programmed death-ligand 1 (PD-1/PD-L1), leading to T cell anergy. Therefore, cancer immunotherapy with specific binding...

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Bibliographic Details
Main Authors: Sirintra Sirivisoot, Chatikorn Boonkrai, Tossapon Wongtangprasert, Tanapati Phakham, Phijitra Muanwein, Trairak Pisitkun, Chenphop Sawangmake, Araya Radtanakatikanon, Anudep Rungsipipat
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Veterinary Quarterly
Subjects:
Dog
canine PD-L1
anti-canine PD-L1 antibody
immune checkpoint inhibitor
Online Access:https://www.tandfonline.com/doi/10.1080/01652176.2023.2240380

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