COVID-19 and Health Outcomes in People with Multiple Sclerosis: A Population-Based Study in Italy
People with multiple sclerosis (PWMS) are at high risk of being affected by the disruption of health services that occurred during the COVID-19 pandemic months. The aim of this study was to evaluate the effect of the pandemic on the health outcomes of PWMS. PWMS and MS-free residing in Piedmont (nor...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/5/1089 |
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| author | Roberto Gnavi Ilenia Eboli Paolo Emilio Alboini Sandra D’Alfonso Roberta Picariello Giuseppe Costa Maurizio Leone |
| author_facet | Roberto Gnavi Ilenia Eboli Paolo Emilio Alboini Sandra D’Alfonso Roberta Picariello Giuseppe Costa Maurizio Leone |
| author_sort | Roberto Gnavi |
| collection | DOAJ |
| description | People with multiple sclerosis (PWMS) are at high risk of being affected by the disruption of health services that occurred during the COVID-19 pandemic months. The aim of this study was to evaluate the effect of the pandemic on the health outcomes of PWMS. PWMS and MS-free residing in Piedmont (north-west of Italy) were identified from electronic health records and linked with the regional COVID-19 database, the hospital-discharge database, and the population registry. Both cohorts (9333 PWMS and 4,145,856 MS-free persons) were followed-up for access to swab testing, hospitalisation, access to the Intensive Care Unit (ICU), and death from 22 February 2020 to 30 April 2021. The relationship between the outcomes and MS was evaluated using a logistic model, which was adjusted for potential confounders. The rate of swab testing was higher in PWMS, but the positivity to infection was similar to that of MS-free subjects. PWMS had a higher risk of hospitalisation (OR = 1.74; 95% IC, 1.41–2.14), admission to ICU (OR = 1.79; 95% IC, 1.17–2.72), and a slight, albeit not statistically significant, increase in mortality (OR = 1.28; 95% IC, 0.79–2.06). Compared to the general population PWMS with COVID-19 had an increased risk of hospitalization and admission to the ICU; the mortality rate did not differ. |
| first_indexed | 2024-03-11T03:34:53Z |
| format | Article |
| id | doaj.art-dbea99c55dbe47b5a5c484d9cba0fc69 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T03:34:53Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-dbea99c55dbe47b5a5c484d9cba0fc692023-11-18T02:08:31ZengMDPI AGLife2075-17292023-04-01135108910.3390/life13051089COVID-19 and Health Outcomes in People with Multiple Sclerosis: A Population-Based Study in ItalyRoberto Gnavi0Ilenia Eboli1Paolo Emilio Alboini2Sandra D’Alfonso3Roberta Picariello4Giuseppe Costa5Maurizio Leone6Epidemiology Unit, ASL TO3 Regione Piemonte, 10095 Grugliasco, ItalyEpidemiology Unit, ASL TO3 Regione Piemonte, 10095 Grugliasco, ItalyNeurology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyDepartment of Health Sciences, and CAAD, University of Eastern Piedmont, 28100 Novara, ItalyEpidemiology Unit, ASL TO3 Regione Piemonte, 10095 Grugliasco, ItalyEpidemiology Unit, ASL TO3 Regione Piemonte, 10095 Grugliasco, ItalyNeurology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyPeople with multiple sclerosis (PWMS) are at high risk of being affected by the disruption of health services that occurred during the COVID-19 pandemic months. The aim of this study was to evaluate the effect of the pandemic on the health outcomes of PWMS. PWMS and MS-free residing in Piedmont (north-west of Italy) were identified from electronic health records and linked with the regional COVID-19 database, the hospital-discharge database, and the population registry. Both cohorts (9333 PWMS and 4,145,856 MS-free persons) were followed-up for access to swab testing, hospitalisation, access to the Intensive Care Unit (ICU), and death from 22 February 2020 to 30 April 2021. The relationship between the outcomes and MS was evaluated using a logistic model, which was adjusted for potential confounders. The rate of swab testing was higher in PWMS, but the positivity to infection was similar to that of MS-free subjects. PWMS had a higher risk of hospitalisation (OR = 1.74; 95% IC, 1.41–2.14), admission to ICU (OR = 1.79; 95% IC, 1.17–2.72), and a slight, albeit not statistically significant, increase in mortality (OR = 1.28; 95% IC, 0.79–2.06). Compared to the general population PWMS with COVID-19 had an increased risk of hospitalization and admission to the ICU; the mortality rate did not differ.https://www.mdpi.com/2075-1729/13/5/1089multiple sclerosisCOVID-19outcome assessmenthealth care |
| spellingShingle | Roberto Gnavi Ilenia Eboli Paolo Emilio Alboini Sandra D’Alfonso Roberta Picariello Giuseppe Costa Maurizio Leone COVID-19 and Health Outcomes in People with Multiple Sclerosis: A Population-Based Study in Italy Life multiple sclerosis COVID-19 outcome assessment health care |
| title | COVID-19 and Health Outcomes in People with Multiple Sclerosis: A Population-Based Study in Italy |
| title_full | COVID-19 and Health Outcomes in People with Multiple Sclerosis: A Population-Based Study in Italy |
| title_fullStr | COVID-19 and Health Outcomes in People with Multiple Sclerosis: A Population-Based Study in Italy |
| title_full_unstemmed | COVID-19 and Health Outcomes in People with Multiple Sclerosis: A Population-Based Study in Italy |
| title_short | COVID-19 and Health Outcomes in People with Multiple Sclerosis: A Population-Based Study in Italy |
| title_sort | covid 19 and health outcomes in people with multiple sclerosis a population based study in italy |
| topic | multiple sclerosis COVID-19 outcome assessment health care |
| url | https://www.mdpi.com/2075-1729/13/5/1089 |
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