Treatment of Severe Japanese Encephalitis Complicated With Hashimoto’s Thyroiditis and Guillain-Barré Syndrome With Protein A Immunoadsorption: A Case Report
A severely comatose female patient was diagnosed with Japanese encephalitis (JE). Her condition was complicated by Hashimoto’s thyroiditis (HT) and Guillain-Barré syndrome (GBS). After antiviral, glucocorticoid, and immunoglobulin treatment, the patient’s consciousness was restored, and she could br...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.807937/full |
| _version_ | 1818750215167934464 |
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| author | Qiuling Zang Yating Wang Junshuang Guo Liyang Long Shuyu Zhang Can Cui Dandan Song Boguang Yu Fenlan Tang Junfang Teng Wang Miao |
| author_facet | Qiuling Zang Yating Wang Junshuang Guo Liyang Long Shuyu Zhang Can Cui Dandan Song Boguang Yu Fenlan Tang Junfang Teng Wang Miao |
| author_sort | Qiuling Zang |
| collection | DOAJ |
| description | A severely comatose female patient was diagnosed with Japanese encephalitis (JE). Her condition was complicated by Hashimoto’s thyroiditis (HT) and Guillain-Barré syndrome (GBS). After antiviral, glucocorticoid, and immunoglobulin treatment, the patient’s consciousness was restored, and she could breathe spontaneously. Following this, new-onset, primarily demyelinating GBS developed, which progressed to demyelination combined with axonal injury. The patient was switched to protein A immunoadsorption (PAIA) therapy, and her Hughes score decreased rapidly, from 4 to 1 after 6 months. This patient is the first to receive PAIA combined with an antiviral-glucocorticoid-immunoglobulin regimen to treat encephalitis, meningitis, HT, and GBS caused by JE infection, thereby reflecting the importance of clinical application of PAIA in the treatment of immunological complications of JE. |
| first_indexed | 2024-12-18T04:16:08Z |
| format | Article |
| id | doaj.art-dbeae804b02345fd86096fdc52f2f33f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-18T04:16:08Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-dbeae804b02345fd86096fdc52f2f33f2022-12-21T21:21:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-01-011210.3389/fimmu.2021.807937807937Treatment of Severe Japanese Encephalitis Complicated With Hashimoto’s Thyroiditis and Guillain-Barré Syndrome With Protein A Immunoadsorption: A Case ReportQiuling Zang0Yating Wang1Junshuang Guo2Liyang Long3Shuyu Zhang4Can Cui5Dandan Song6Boguang Yu7Fenlan Tang8Junfang Teng9Wang Miao10Neuro-intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaNeuro-intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaNeuro-intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaTraditional Chinese Medicine Hospital of Qiandongnan Miao and Dong Autonomous Prefecture, Kaili, ChinaNeuro-intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaNeuro-intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaNeuro-intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaGuangdong Provincial Key Laboratory of Hemoadsorption Technology, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Hemoadsorption Technology, Guangzhou, ChinaNeuro-intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaNeuro-intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaA severely comatose female patient was diagnosed with Japanese encephalitis (JE). Her condition was complicated by Hashimoto’s thyroiditis (HT) and Guillain-Barré syndrome (GBS). After antiviral, glucocorticoid, and immunoglobulin treatment, the patient’s consciousness was restored, and she could breathe spontaneously. Following this, new-onset, primarily demyelinating GBS developed, which progressed to demyelination combined with axonal injury. The patient was switched to protein A immunoadsorption (PAIA) therapy, and her Hughes score decreased rapidly, from 4 to 1 after 6 months. This patient is the first to receive PAIA combined with an antiviral-glucocorticoid-immunoglobulin regimen to treat encephalitis, meningitis, HT, and GBS caused by JE infection, thereby reflecting the importance of clinical application of PAIA in the treatment of immunological complications of JE.https://www.frontiersin.org/articles/10.3389/fimmu.2021.807937/fullJapanese encephalitisGuillain-Barré syndromeHashimoto’s thyroiditisprotein A immunoadsorptioncase report |
| spellingShingle | Qiuling Zang Yating Wang Junshuang Guo Liyang Long Shuyu Zhang Can Cui Dandan Song Boguang Yu Fenlan Tang Junfang Teng Wang Miao Treatment of Severe Japanese Encephalitis Complicated With Hashimoto’s Thyroiditis and Guillain-Barré Syndrome With Protein A Immunoadsorption: A Case Report Frontiers in Immunology Japanese encephalitis Guillain-Barré syndrome Hashimoto’s thyroiditis protein A immunoadsorption case report |
| title | Treatment of Severe Japanese Encephalitis Complicated With Hashimoto’s Thyroiditis and Guillain-Barré Syndrome With Protein A Immunoadsorption: A Case Report |
| title_full | Treatment of Severe Japanese Encephalitis Complicated With Hashimoto’s Thyroiditis and Guillain-Barré Syndrome With Protein A Immunoadsorption: A Case Report |
| title_fullStr | Treatment of Severe Japanese Encephalitis Complicated With Hashimoto’s Thyroiditis and Guillain-Barré Syndrome With Protein A Immunoadsorption: A Case Report |
| title_full_unstemmed | Treatment of Severe Japanese Encephalitis Complicated With Hashimoto’s Thyroiditis and Guillain-Barré Syndrome With Protein A Immunoadsorption: A Case Report |
| title_short | Treatment of Severe Japanese Encephalitis Complicated With Hashimoto’s Thyroiditis and Guillain-Barré Syndrome With Protein A Immunoadsorption: A Case Report |
| title_sort | treatment of severe japanese encephalitis complicated with hashimoto s thyroiditis and guillain barre syndrome with protein a immunoadsorption a case report |
| topic | Japanese encephalitis Guillain-Barré syndrome Hashimoto’s thyroiditis protein A immunoadsorption case report |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.807937/full |
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