How Lineage Tracing Studies Can Unveil Tumor Heterogeneity in Breast Cancer
Lineage tracing studies have become a well-suited approach to reveal cellular hierarchies and tumor heterogeneity. Cellular heterogeneity, particularly in breast cancer, is still one of the main concerns regarding tumor progression and resistance to anti-cancer therapies. Here, we review the current...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/1/3 |
| _version_ | 1827666560614924288 |
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| author | Elena Vinuesa-Pitarch Daniel Ortega-Álvarez Verónica Rodilla |
| author_facet | Elena Vinuesa-Pitarch Daniel Ortega-Álvarez Verónica Rodilla |
| author_sort | Elena Vinuesa-Pitarch |
| collection | DOAJ |
| description | Lineage tracing studies have become a well-suited approach to reveal cellular hierarchies and tumor heterogeneity. Cellular heterogeneity, particularly in breast cancer, is still one of the main concerns regarding tumor progression and resistance to anti-cancer therapies. Here, we review the current knowledge about lineage tracing analyses that have contributed to an improved comprehension of the complexity of mammary tumors, highlighting how targeting different mammary epithelial cells and tracing their progeny can be useful to explore the intra- and inter-heterogeneity observed in breast cancer. In addition, we examine the strategies used to identify the cell of origin in different breast cancer subtypes and summarize how cellular plasticity plays an important role during tumorigenesis. Finally, we evaluate the clinical implications of lineage tracing studies and the challenges remaining to address tumor heterogeneity in breast cancer. |
| first_indexed | 2024-03-10T01:53:23Z |
| format | Article |
| id | doaj.art-dbeb4bf9c84e405190c380098a4a7c55 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T01:53:23Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-dbeb4bf9c84e405190c380098a4a7c552023-11-23T13:02:06ZengMDPI AGBiomedicines2227-90592021-12-01101310.3390/biomedicines10010003How Lineage Tracing Studies Can Unveil Tumor Heterogeneity in Breast CancerElena Vinuesa-Pitarch0Daniel Ortega-Álvarez1Verónica Rodilla2Cancer Heterogeneity and Hierarchies Group, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, SpainCancer Heterogeneity and Hierarchies Group, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, SpainCancer Heterogeneity and Hierarchies Group, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, SpainLineage tracing studies have become a well-suited approach to reveal cellular hierarchies and tumor heterogeneity. Cellular heterogeneity, particularly in breast cancer, is still one of the main concerns regarding tumor progression and resistance to anti-cancer therapies. Here, we review the current knowledge about lineage tracing analyses that have contributed to an improved comprehension of the complexity of mammary tumors, highlighting how targeting different mammary epithelial cells and tracing their progeny can be useful to explore the intra- and inter-heterogeneity observed in breast cancer. In addition, we examine the strategies used to identify the cell of origin in different breast cancer subtypes and summarize how cellular plasticity plays an important role during tumorigenesis. Finally, we evaluate the clinical implications of lineage tracing studies and the challenges remaining to address tumor heterogeneity in breast cancer.https://www.mdpi.com/2227-9059/10/1/3breast cancerlineage tracingheterogeneitycellular plasticity |
| spellingShingle | Elena Vinuesa-Pitarch Daniel Ortega-Álvarez Verónica Rodilla How Lineage Tracing Studies Can Unveil Tumor Heterogeneity in Breast Cancer Biomedicines breast cancer lineage tracing heterogeneity cellular plasticity |
| title | How Lineage Tracing Studies Can Unveil Tumor Heterogeneity in Breast Cancer |
| title_full | How Lineage Tracing Studies Can Unveil Tumor Heterogeneity in Breast Cancer |
| title_fullStr | How Lineage Tracing Studies Can Unveil Tumor Heterogeneity in Breast Cancer |
| title_full_unstemmed | How Lineage Tracing Studies Can Unveil Tumor Heterogeneity in Breast Cancer |
| title_short | How Lineage Tracing Studies Can Unveil Tumor Heterogeneity in Breast Cancer |
| title_sort | how lineage tracing studies can unveil tumor heterogeneity in breast cancer |
| topic | breast cancer lineage tracing heterogeneity cellular plasticity |
| url | https://www.mdpi.com/2227-9059/10/1/3 |
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