Functional gradients of the cerebellum
A central principle for understanding the cerebral cortex is that macroscale anatomy reflects a functional hierarchy from primary to transmodal processing. In contrast, the central axis of motor and nonmotor macroscale organization in the cerebellum remains unknown. Here we applied diffusion map emb...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/36652 |
| _version_ | 1811253276589424640 |
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| author | Xavier Guell Jeremy D Schmahmann John DE Gabrieli Satrajit S Ghosh |
| author_facet | Xavier Guell Jeremy D Schmahmann John DE Gabrieli Satrajit S Ghosh |
| author_sort | Xavier Guell |
| collection | DOAJ |
| description | A central principle for understanding the cerebral cortex is that macroscale anatomy reflects a functional hierarchy from primary to transmodal processing. In contrast, the central axis of motor and nonmotor macroscale organization in the cerebellum remains unknown. Here we applied diffusion map embedding to resting-state data from the Human Connectome Project dataset (n = 1003), and show for the first time that cerebellar functional regions follow a gradual organization which progresses from primary (motor) to transmodal (DMN, task-unfocused) regions. A secondary axis extends from task-unfocused to task-focused processing. Further, these two principal gradients revealed novel functional properties of the well-established cerebellar double motor representation (lobules I-VI and VIII), and its relationship with the recently described triple nonmotor representation (lobules VI/Crus I, Crus II/VIIB, IX/X). Functional differences exist not only between the two motor but also between the three nonmotor representations, and second motor representation might share functional similarities with third nonmotor representation. |
| first_indexed | 2024-04-12T16:47:30Z |
| format | Article |
| id | doaj.art-dbeca078678344268fa9083690c053f9 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:47:30Z |
| publishDate | 2018-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-dbeca078678344268fa9083690c053f92022-12-22T03:24:31ZengeLife Sciences Publications LtdeLife2050-084X2018-08-01710.7554/eLife.36652Functional gradients of the cerebellumXavier Guell0https://orcid.org/0000-0002-0684-0954Jeremy D Schmahmann1John DE Gabrieli2Satrajit S Ghosh3https://orcid.org/0000-0002-5312-6729McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States; Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, United StatesLaboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, United States; Ataxia Unit, Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, United StatesMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United StatesMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States; Department of Otolaryngology, Harvard Medical School, Boston, United StatesA central principle for understanding the cerebral cortex is that macroscale anatomy reflects a functional hierarchy from primary to transmodal processing. In contrast, the central axis of motor and nonmotor macroscale organization in the cerebellum remains unknown. Here we applied diffusion map embedding to resting-state data from the Human Connectome Project dataset (n = 1003), and show for the first time that cerebellar functional regions follow a gradual organization which progresses from primary (motor) to transmodal (DMN, task-unfocused) regions. A secondary axis extends from task-unfocused to task-focused processing. Further, these two principal gradients revealed novel functional properties of the well-established cerebellar double motor representation (lobules I-VI and VIII), and its relationship with the recently described triple nonmotor representation (lobules VI/Crus I, Crus II/VIIB, IX/X). Functional differences exist not only between the two motor but also between the three nonmotor representations, and second motor representation might share functional similarities with third nonmotor representation.https://elifesciences.org/articles/36652cerebellumgradientsfMRIresting-statefunctional organizationfunctional topography |
| spellingShingle | Xavier Guell Jeremy D Schmahmann John DE Gabrieli Satrajit S Ghosh Functional gradients of the cerebellum eLife cerebellum gradients fMRI resting-state functional organization functional topography |
| title | Functional gradients of the cerebellum |
| title_full | Functional gradients of the cerebellum |
| title_fullStr | Functional gradients of the cerebellum |
| title_full_unstemmed | Functional gradients of the cerebellum |
| title_short | Functional gradients of the cerebellum |
| title_sort | functional gradients of the cerebellum |
| topic | cerebellum gradients fMRI resting-state functional organization functional topography |
| url | https://elifesciences.org/articles/36652 |
| work_keys_str_mv | AT xavierguell functionalgradientsofthecerebellum AT jeremydschmahmann functionalgradientsofthecerebellum AT johndegabrieli functionalgradientsofthecerebellum AT satrajitsghosh functionalgradientsofthecerebellum |