Research Progress in the Application of Exosomes in Immunotherapy
Exosomes are nanoscale extracellular vesicles (EVs), which are present in all body fluids tested. They are secreted by a variety of cells including macrophages, dendritic cells, mast cells, granulocytes, lymphocytes, and tumor cells. Exosomes secreted by different cells have different biological com...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-02-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.731516/full |
| _version_ | 1818284090159267840 |
|---|---|
| author | Xiaofang Zhang Donggang Xu Yingqiu Song Rong He Tianlu Wang |
| author_facet | Xiaofang Zhang Donggang Xu Yingqiu Song Rong He Tianlu Wang |
| author_sort | Xiaofang Zhang |
| collection | DOAJ |
| description | Exosomes are nanoscale extracellular vesicles (EVs), which are present in all body fluids tested. They are secreted by a variety of cells including macrophages, dendritic cells, mast cells, granulocytes, lymphocytes, and tumor cells. Exosomes secreted by different cells have different biological components and functional characteristics and play an important role in many pathophysiological activities. Recent studies have revealed that exosomes can regulate the occurrence and development of inflammatory immune diseases and tumors by transmitting their unique proteins, lipids, and nucleic acids as signaling molecules to other cells. Exosomes serve as a novel class of diagnostic biomarkers and drug delivery systems with promising applications in immunotherapy, particularly because breakthroughs in nanotechnology have led to the development and exploration of engineered exosomes for immunotargeted therapies. Therefore, here we review the progress being made on the application of exosomes in immunotherapy and its multiple regulatory mechanisms and explore the potential application of exosomes in immunotherapy in the future. |
| first_indexed | 2024-12-13T00:47:16Z |
| format | Article |
| id | doaj.art-dbef4447c66f4bf0918aabc3ead317bf |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T00:47:16Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-dbef4447c66f4bf0918aabc3ead317bf2022-12-22T00:05:01ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-02-011310.3389/fimmu.2022.731516731516Research Progress in the Application of Exosomes in ImmunotherapyXiaofang Zhang0Donggang Xu1Yingqiu Song2Rong He3Tianlu Wang4Department of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, ChinaSecond Clinical Department, Shengjing Hospital, China Medical University, Shenyang, ChinaDepartment of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, ChinaDepartment of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, ChinaDepartment of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, ChinaExosomes are nanoscale extracellular vesicles (EVs), which are present in all body fluids tested. They are secreted by a variety of cells including macrophages, dendritic cells, mast cells, granulocytes, lymphocytes, and tumor cells. Exosomes secreted by different cells have different biological components and functional characteristics and play an important role in many pathophysiological activities. Recent studies have revealed that exosomes can regulate the occurrence and development of inflammatory immune diseases and tumors by transmitting their unique proteins, lipids, and nucleic acids as signaling molecules to other cells. Exosomes serve as a novel class of diagnostic biomarkers and drug delivery systems with promising applications in immunotherapy, particularly because breakthroughs in nanotechnology have led to the development and exploration of engineered exosomes for immunotargeted therapies. Therefore, here we review the progress being made on the application of exosomes in immunotherapy and its multiple regulatory mechanisms and explore the potential application of exosomes in immunotherapy in the future.https://www.frontiersin.org/articles/10.3389/fimmu.2022.731516/fullexosomesimmunomodulatoryimmunotherapywireless communicationmolecules transmitting |
| spellingShingle | Xiaofang Zhang Donggang Xu Yingqiu Song Rong He Tianlu Wang Research Progress in the Application of Exosomes in Immunotherapy Frontiers in Immunology exosomes immunomodulatory immunotherapy wireless communication molecules transmitting |
| title | Research Progress in the Application of Exosomes in Immunotherapy |
| title_full | Research Progress in the Application of Exosomes in Immunotherapy |
| title_fullStr | Research Progress in the Application of Exosomes in Immunotherapy |
| title_full_unstemmed | Research Progress in the Application of Exosomes in Immunotherapy |
| title_short | Research Progress in the Application of Exosomes in Immunotherapy |
| title_sort | research progress in the application of exosomes in immunotherapy |
| topic | exosomes immunomodulatory immunotherapy wireless communication molecules transmitting |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.731516/full |
| work_keys_str_mv | AT xiaofangzhang researchprogressintheapplicationofexosomesinimmunotherapy AT donggangxu researchprogressintheapplicationofexosomesinimmunotherapy AT yingqiusong researchprogressintheapplicationofexosomesinimmunotherapy AT ronghe researchprogressintheapplicationofexosomesinimmunotherapy AT tianluwang researchprogressintheapplicationofexosomesinimmunotherapy |