High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11

High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11

ABSTRACT Fungal infections contribute to over 1.5 million deaths annually, with Candida albicans representing one of the most concerning human fungal pathogens. While normally commensal in nature, compromise of host immunity can result in C. albicans disseminating into the human bloodstream, causing...

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Bibliographic Details
Main Authors: Antonia C. Du Bois, Alice Xue, Chester Pham, Nicole M. Revie, Kirsten J. Meyer, Yoko Yashiroda, Charles Boone, Justin R. Nodwell, Peter Stogios, Alexei Savchenko, Nicole Robbins, Kali R. Iyer, Leah E. Cowen
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mSphere
Subjects:
2
5-disubstituted pyridine
Candida albicans
Erg11
azole
chemogenomics
Online Access:https://journals.asm.org/doi/10.1128/msphere.00075-22

Internet

https://journals.asm.org/doi/10.1128/msphere.00075-22

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