Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes

Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes

Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer’s disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease. Based on the crystal structure of previously described highly potent, revers...

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Những tác giả chính: Stane Pajk, Damijan Knez, Urban Košak, Maja Zorović, Xavier Brazzolotto, Nicolas Coquelle, Florian Nachon, Jacques-Philippe Colletier, Marko Živin, Jure Stojan, Stanislav Gobec
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Taylor & Francis Group 2020-01-01
Loạt:Journal of Enzyme Inhibition and Medicinal Chemistry
Những chủ đề:
butyrylcholinesterase
inhibitor
probe
fluorescence
Truy cập trực tuyến:http://dx.doi.org/10.1080/14756366.2019.1710502

Internet

http://dx.doi.org/10.1080/14756366.2019.1710502

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