Relationship between hair cortisol concentrations and cognitive functioning in adolescents with ADHD
ABSTRACTBackground: Our study aimed to explore whether the hair cortisol concentration (HCC), a measure of long-term cortisol output, is associated with poorer cognitive functioning in adolescents with attention deficit and hyperactivity disorder (ADHD). We further aimed to test the potential modera...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-11-01
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| Series: | European Journal of Psychotraumatology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/20008066.2023.2281752 |
| _version_ | 1827696096646791168 |
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| author | Marta Llorens Maria Barba Jordi Torralbas-Ortega Roser Nadal Antonio Armario Humberto Gagliano Lara Urraca Susana Pujol Itziar Montalvo Rebeca Gracia Diana Polo Laura González-Riesco Josep Lluís Matalí Diego Palao Montserrat Pàmias Javier Labad |
| author_facet | Marta Llorens Maria Barba Jordi Torralbas-Ortega Roser Nadal Antonio Armario Humberto Gagliano Lara Urraca Susana Pujol Itziar Montalvo Rebeca Gracia Diana Polo Laura González-Riesco Josep Lluís Matalí Diego Palao Montserrat Pàmias Javier Labad |
| author_sort | Marta Llorens |
| collection | DOAJ |
| description | ABSTRACTBackground: Our study aimed to explore whether the hair cortisol concentration (HCC), a measure of long-term cortisol output, is associated with poorer cognitive functioning in adolescents with attention deficit and hyperactivity disorder (ADHD). We further aimed to test the potential moderating effects of sex and childhood maltreatment.Methods: In this cross-sectional study, fifty-three adolescents with ADHD were studied. The ADHD Rating Scale (ADHD-RS) and Childhood Trauma Questionnaire (CTQ) were administered. Seven cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB) were administered, and two cognitive factors (attention and memory and executive functioning) were identified by confirmatory factor analysis. A 3-cm hair sample from the posterior vertex region of the head was obtained. HCCs were determined by a high-sensitivity enzyme immunoassay kit. Multiple linear regression analyses were used to explore the association between HCCs and either cognitive performance or ADHD severity while adjusting for sex, childhood maltreatment and the ADHD-RS total score.Results: Sex moderated the relationship between HCCs and attention/memory confirmatory factor analysis (CFA) scores, with better performance in boys with higher HCCs. HCCs were not associated with executive functioning or ADHD symptoms. Childhood maltreatment was associated with inattention symptoms in adolescents with ADHD.Conclusions: Our study suggests that HCCs are positively associated with attention and memory performance in adolescents with ADHD, with a moderating effect of sex (the relationship is strongest in boys). |
| first_indexed | 2024-03-10T12:40:03Z |
| format | Article |
| id | doaj.art-dbf18e2ad6ba4f17a28df427d93c1c6e |
| institution | Directory Open Access Journal |
| issn | 2000-8066 |
| language | English |
| last_indexed | 2024-03-10T12:40:03Z |
| publishDate | 2023-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | European Journal of Psychotraumatology |
| spelling | doaj.art-dbf18e2ad6ba4f17a28df427d93c1c6e2023-11-21T13:58:44ZengTaylor & Francis GroupEuropean Journal of Psychotraumatology2000-80662023-11-0114210.1080/20008066.2023.2281752Relationship between hair cortisol concentrations and cognitive functioning in adolescents with ADHDMarta Llorens0Maria Barba1Jordi Torralbas-Ortega2Roser Nadal3Antonio Armario4Humberto Gagliano5Lara Urraca6Susana Pujol7Itziar Montalvo8Rebeca Gracia9Diana Polo10Laura González-Riesco11Josep Lluís Matalí12Diego Palao13Montserrat Pàmias14Javier Labad15Department of Child and Adolescent Mental Health, Hospital Sant Joan de Déu, Barcelona, SpainDepartment of Mental Health, Parc Taulí Hospital Universitari, Sabadell, SpainNursing Care Research Group, Sant Pau Biomedical Research Institute (IIB SANTPAU). Hospital de la Santa Creu i Sant Pau, Barcelona, SpainInstitut de Neurociències, Translational Neuroscience Research Unit I3PT-INc-UAB, Sabadell, SpainInstitut de Neurociències, Translational Neuroscience Research Unit I3PT-INc-UAB, Sabadell, SpainAnimal Physiology Unit (Department of Cellular Biology, Physiology and Immunology), Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, SpainDepartment of Mental Health, Parc Taulí Hospital Universitari, Sabadell, SpainDepartment of Mental Health, Parc Taulí Hospital Universitari, Sabadell, SpainDepartment of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Bellaterra, SpainDepartment of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Bellaterra, SpainDepartment of Child and Adolescent Mental Health, Hospital Sant Joan de Déu, Barcelona, SpainDepartment of Child and Adolescent Mental Health, Hospital Sant Joan de Déu, Barcelona, SpainDepartment of Child and Adolescent Mental Health, Hospital Sant Joan de Déu, Barcelona, SpainDepartment of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Bellaterra, SpainDepartment of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Bellaterra, SpainDepartment of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Bellaterra, SpainABSTRACTBackground: Our study aimed to explore whether the hair cortisol concentration (HCC), a measure of long-term cortisol output, is associated with poorer cognitive functioning in adolescents with attention deficit and hyperactivity disorder (ADHD). We further aimed to test the potential moderating effects of sex and childhood maltreatment.Methods: In this cross-sectional study, fifty-three adolescents with ADHD were studied. The ADHD Rating Scale (ADHD-RS) and Childhood Trauma Questionnaire (CTQ) were administered. Seven cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB) were administered, and two cognitive factors (attention and memory and executive functioning) were identified by confirmatory factor analysis. A 3-cm hair sample from the posterior vertex region of the head was obtained. HCCs were determined by a high-sensitivity enzyme immunoassay kit. Multiple linear regression analyses were used to explore the association between HCCs and either cognitive performance or ADHD severity while adjusting for sex, childhood maltreatment and the ADHD-RS total score.Results: Sex moderated the relationship between HCCs and attention/memory confirmatory factor analysis (CFA) scores, with better performance in boys with higher HCCs. HCCs were not associated with executive functioning or ADHD symptoms. Childhood maltreatment was associated with inattention symptoms in adolescents with ADHD.Conclusions: Our study suggests that HCCs are positively associated with attention and memory performance in adolescents with ADHD, with a moderating effect of sex (the relationship is strongest in boys).https://www.tandfonline.com/doi/10.1080/20008066.2023.2281752CortisolstressADHDcognitionchildhood traumasex |
| spellingShingle | Marta Llorens Maria Barba Jordi Torralbas-Ortega Roser Nadal Antonio Armario Humberto Gagliano Lara Urraca Susana Pujol Itziar Montalvo Rebeca Gracia Diana Polo Laura González-Riesco Josep Lluís Matalí Diego Palao Montserrat Pàmias Javier Labad Relationship between hair cortisol concentrations and cognitive functioning in adolescents with ADHD European Journal of Psychotraumatology Cortisol stress ADHD cognition childhood trauma sex |
| title | Relationship between hair cortisol concentrations and cognitive functioning in adolescents with ADHD |
| title_full | Relationship between hair cortisol concentrations and cognitive functioning in adolescents with ADHD |
| title_fullStr | Relationship between hair cortisol concentrations and cognitive functioning in adolescents with ADHD |
| title_full_unstemmed | Relationship between hair cortisol concentrations and cognitive functioning in adolescents with ADHD |
| title_short | Relationship between hair cortisol concentrations and cognitive functioning in adolescents with ADHD |
| title_sort | relationship between hair cortisol concentrations and cognitive functioning in adolescents with adhd |
| topic | Cortisol stress ADHD cognition childhood trauma sex |
| url | https://www.tandfonline.com/doi/10.1080/20008066.2023.2281752 |
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