Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Bispecific T-cell-engaging antibodies are a growing class of therapeutics with numerous molecules being tested in clinical trials and, currently, seven of them have received market approval. They are structurally complex and function as adaptors to redirect the cytotoxicity of T cells to kill tumor...

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Autori principali: Nishant Mohan, Safiat Ayinde, Hanjing Peng, Shraboni Dutta, Yi Shen, Vincent M. Falkowski, Thomas G. Biel, Tongzhong Ju, Wen Jin Wu
Natura: Articolo
Lingua:English
Pubblicazione: Frontiers Media S.A. 2024-05-01
Serie:Frontiers in Immunology
Soggetti:
bispecific antibody
bispecific T-cell engager
epidermal growth factor receptor (EGFR)
cluster of differentiation 3 (CD3)
dual variable domain immunoglobulins (DVD-Ig)
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376096/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376096/full

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