Autophagy inhibitor LRPPRC suppresses mitophagy through interaction with mitophagy initiator Parkin.

Autophagy inhibitor LRPPRC suppresses mitophagy through interaction with mitophagy initiator Parkin.

Autophagy plays an important role in tumorigenesis. Mitochondrion-associated protein LRPPRC interacts with MAP1S that interacts with LC3 and bridges autophagy components with microtubules and mitochondria to affect autophagy flux. Dysfunction of LRPPRC and MAP1S is associated with poor survival of o...

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Bibliographic Details
Main Authors: Jing Zou, Fei Yue, Wenjiao Li, Kun Song, Xianhan Jiang, Jinglin Yi, Leyuan Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3983268?pdf=render

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