Post-weaning folate deficiency induces a depression-like state via neuronal immaturity of the dentate gyrus in mice
Folate deficiency has been suggested as a risk factor for depression in preclinical and clinical studies. Several hypotheses of mechanisms underlying folate deficiency-induced depressive symptoms have been proposed, but the detailed mechanisms are still unclear. In this study, we assessed whether po...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Journal of Pharmacological Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861320300219 |
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| author | Shoji Nishida Ryota Araki Akihiro Baba Sota Asari Shin Tachibana Yuki Nakajima Arimi Iwakumo Takeshi Yabe |
| author_facet | Shoji Nishida Ryota Araki Akihiro Baba Sota Asari Shin Tachibana Yuki Nakajima Arimi Iwakumo Takeshi Yabe |
| author_sort | Shoji Nishida |
| collection | DOAJ |
| description | Folate deficiency has been suggested as a risk factor for depression in preclinical and clinical studies. Several hypotheses of mechanisms underlying folate deficiency-induced depressive symptoms have been proposed, but the detailed mechanisms are still unclear. In this study, we assessed whether post-weaning folate deficiency affect neurological and psychological function. The low folate diet-fed mice showed depression-like behavior in the forced swim test. In contrast, spontaneous locomotor activity, social behavior, coordinated motor skills, anxiety-like behavior and spatial memory did not differ between control and low folate diet-fed mice. In the dentate gyrus (DG) of the hippocampus, decreased number of newborn mature neurons and increased number of immature neurons were observed in low folate diet-fed mice. Staining with Golgi-Cox method revealed that dendritic complexity, spine density and the number of mature spines of neurons were markedly reduced in the DG of low folate diet-fed mice. Stress response of neurons indicated as c-Fos expression was also reduced in the DG of low folate diet-fed mice. These results suggest that reduction in the degree of maturation of newborn hippocampal neurons underlies folate deficiency-induced depressive symptoms. |
| first_indexed | 2024-12-19T03:00:41Z |
| format | Article |
| id | doaj.art-dbf442636f0540a3a0cf29d424d0957c |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-19T03:00:41Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-dbf442636f0540a3a0cf29d424d0957c2022-12-21T20:38:12ZengElsevierJournal of Pharmacological Sciences1347-86132020-06-01143297105Post-weaning folate deficiency induces a depression-like state via neuronal immaturity of the dentate gyrus in miceShoji Nishida0Ryota Araki1Akihiro Baba2Sota Asari3Shin Tachibana4Yuki Nakajima5Arimi Iwakumo6Takeshi Yabe7Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, JapanCorresponding author. Fax: +81 72 800-1176.; Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, JapanLaboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, JapanLaboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, JapanLaboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, JapanLaboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, JapanLaboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, JapanCorresponding author. Fax: +81 72 800-1198.; Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, JapanFolate deficiency has been suggested as a risk factor for depression in preclinical and clinical studies. Several hypotheses of mechanisms underlying folate deficiency-induced depressive symptoms have been proposed, but the detailed mechanisms are still unclear. In this study, we assessed whether post-weaning folate deficiency affect neurological and psychological function. The low folate diet-fed mice showed depression-like behavior in the forced swim test. In contrast, spontaneous locomotor activity, social behavior, coordinated motor skills, anxiety-like behavior and spatial memory did not differ between control and low folate diet-fed mice. In the dentate gyrus (DG) of the hippocampus, decreased number of newborn mature neurons and increased number of immature neurons were observed in low folate diet-fed mice. Staining with Golgi-Cox method revealed that dendritic complexity, spine density and the number of mature spines of neurons were markedly reduced in the DG of low folate diet-fed mice. Stress response of neurons indicated as c-Fos expression was also reduced in the DG of low folate diet-fed mice. These results suggest that reduction in the degree of maturation of newborn hippocampal neurons underlies folate deficiency-induced depressive symptoms.http://www.sciencedirect.com/science/article/pii/S1347861320300219FolateDepressionHippocampusNeuronal immaturity |
| spellingShingle | Shoji Nishida Ryota Araki Akihiro Baba Sota Asari Shin Tachibana Yuki Nakajima Arimi Iwakumo Takeshi Yabe Post-weaning folate deficiency induces a depression-like state via neuronal immaturity of the dentate gyrus in mice Journal of Pharmacological Sciences Folate Depression Hippocampus Neuronal immaturity |
| title | Post-weaning folate deficiency induces a depression-like state via neuronal immaturity of the dentate gyrus in mice |
| title_full | Post-weaning folate deficiency induces a depression-like state via neuronal immaturity of the dentate gyrus in mice |
| title_fullStr | Post-weaning folate deficiency induces a depression-like state via neuronal immaturity of the dentate gyrus in mice |
| title_full_unstemmed | Post-weaning folate deficiency induces a depression-like state via neuronal immaturity of the dentate gyrus in mice |
| title_short | Post-weaning folate deficiency induces a depression-like state via neuronal immaturity of the dentate gyrus in mice |
| title_sort | post weaning folate deficiency induces a depression like state via neuronal immaturity of the dentate gyrus in mice |
| topic | Folate Depression Hippocampus Neuronal immaturity |
| url | http://www.sciencedirect.com/science/article/pii/S1347861320300219 |
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