Clostridioides difficile infection leading to fulminant colitis with toxic megacolon
Clostridioides difficile infection (CDI) is the culprit of millions of nosocomial infections in the United States. Programs that successfully decrease its incidence, therefore, render cost savings for the healthcare system. Toxic megacolon and perforation are two of the most significant complicatio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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University of São Paulo
2023-11-01
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| Series: | Autopsy and Case Reports |
| Subjects: | |
| Online Access: | https://www.revistas.usp.br/autopsy/article/view/219233 |
| _version_ | 1797449992830451712 |
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| author | Fareed Rajack Shawn Medford Tammey Naab |
| author_facet | Fareed Rajack Shawn Medford Tammey Naab |
| author_sort | Fareed Rajack |
| collection | DOAJ |
| description |
Clostridioides difficile infection (CDI) is the culprit of millions of nosocomial infections in the United States. Programs
that successfully decrease its incidence, therefore, render cost savings for the healthcare system. Toxic megacolon and
perforation are two of the most significant complications with increased mortality rates. We report a 23-year-old nursing
home resident hospitalized for fever, cough, and green sputum. After 3 days of antibiotic therapy, he developed abdominal
distension, diarrhea, and vomiting and underwent a total colectomy. The colon was dilated to a maximum of 11 cm
with markedly edematous mucosa and yellow pseudomembranes. Qualitative PCR of the stool detected Clostridioides
difficile toxin B gene. While there is no consensus for the required interval between antibiotic treatment and CDI, this
presentation 3 days after starting the antibiotic therapy is earlier than most proposed ranges.
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| first_indexed | 2024-03-09T14:33:07Z |
| format | Article |
| id | doaj.art-dbf5eda643db425f8e012f29a5baf83d |
| institution | Directory Open Access Journal |
| issn | 2236-1960 |
| language | English |
| last_indexed | 2024-03-09T14:33:07Z |
| publishDate | 2023-11-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Autopsy and Case Reports |
| spelling | doaj.art-dbf5eda643db425f8e012f29a5baf83d2023-11-27T17:29:44ZengUniversity of São PauloAutopsy and Case Reports2236-19602023-11-0113Clostridioides difficile infection leading to fulminant colitis with toxic megacolonFareed Rajack0Shawn Medford1Tammey Naab2 Howard University Hospital, Department of Pathology and Laboratory Medicine, Washington, D.C., United States of America Howard University College of Medicine, Washington, D.C., United States of America Howard University Hospital, Department of Pathology and Laboratory Medicine, Washington, D.C., United States of America Clostridioides difficile infection (CDI) is the culprit of millions of nosocomial infections in the United States. Programs that successfully decrease its incidence, therefore, render cost savings for the healthcare system. Toxic megacolon and perforation are two of the most significant complications with increased mortality rates. We report a 23-year-old nursing home resident hospitalized for fever, cough, and green sputum. After 3 days of antibiotic therapy, he developed abdominal distension, diarrhea, and vomiting and underwent a total colectomy. The colon was dilated to a maximum of 11 cm with markedly edematous mucosa and yellow pseudomembranes. Qualitative PCR of the stool detected Clostridioides difficile toxin B gene. While there is no consensus for the required interval between antibiotic treatment and CDI, this presentation 3 days after starting the antibiotic therapy is earlier than most proposed ranges. https://www.revistas.usp.br/autopsy/article/view/219233ColectomyColitisColorectal SurgeryDiarrhea, Pseudomembranous |
| spellingShingle | Fareed Rajack Shawn Medford Tammey Naab Clostridioides difficile infection leading to fulminant colitis with toxic megacolon Autopsy and Case Reports Colectomy Colitis Colorectal Surgery Diarrhea, Pseudomembranous |
| title | Clostridioides difficile infection leading to fulminant colitis with toxic megacolon |
| title_full | Clostridioides difficile infection leading to fulminant colitis with toxic megacolon |
| title_fullStr | Clostridioides difficile infection leading to fulminant colitis with toxic megacolon |
| title_full_unstemmed | Clostridioides difficile infection leading to fulminant colitis with toxic megacolon |
| title_short | Clostridioides difficile infection leading to fulminant colitis with toxic megacolon |
| title_sort | clostridioides difficile infection leading to fulminant colitis with toxic megacolon |
| topic | Colectomy Colitis Colorectal Surgery Diarrhea, Pseudomembranous |
| url | https://www.revistas.usp.br/autopsy/article/view/219233 |
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