Squamous Cell Skin Carcinoma in Systemic Lupus Erythematosus: Case Report and Literature Review
The case report of squamous cell skin carcinoma diagnosed in a patient with systemic lupus erythematosus 26 years after the onset of rheumatic disease is presented. The features of this case included the absence of skin manifestations of systemic lupus erythematosus, the occurrence of a tumor at the...
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| Format: | Article |
| Language: | Russian |
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SINAPS LLC
2020-10-01
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| Series: | Архивъ внутренней медицины |
| Subjects: | |
| Online Access: | https://www.medarhive.ru/jour/article/view/1092 |
| _version_ | 1797883740006907904 |
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| author | S. V. Topolyanskaya |
| author_facet | S. V. Topolyanskaya |
| author_sort | S. V. Topolyanskaya |
| collection | DOAJ |
| description | The case report of squamous cell skin carcinoma diagnosed in a patient with systemic lupus erythematosus 26 years after the onset of rheumatic disease is presented. The features of this case included the absence of skin manifestations of systemic lupus erythematosus, the occurrence of a tumor at the site of ulcers and trophic disorders on the leg, a long period (6 years) from the onset of a ulcerative defect on the leg to the diagnosis of skin cancer (despite multiple biopsies and consultations of various specialists), as well as the occurrence of a cytokine release syndrome, which directly led to the death of the patient after the first use of the immune checkpoint inhibitors. Possible causes of skin cancer in patients with systemic lupus erythematosus, as well as the features of the cytokine release syndrome after immunotherapy for oncological diseases, are discussed. |
| first_indexed | 2024-04-10T03:56:36Z |
| format | Article |
| id | doaj.art-dbfac1d60f164f4aadc3398cc99414a1 |
| institution | Directory Open Access Journal |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| last_indexed | 2024-04-10T03:56:36Z |
| publishDate | 2020-10-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj.art-dbfac1d60f164f4aadc3398cc99414a12023-03-13T07:12:10ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642020-10-0110539039710.20514/2226-6704-2020-10-5-390-397812Squamous Cell Skin Carcinoma in Systemic Lupus Erythematosus: Case Report and Literature ReviewS. V. Topolyanskaya0ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения РФ (Сеченовский Университет)The case report of squamous cell skin carcinoma diagnosed in a patient with systemic lupus erythematosus 26 years after the onset of rheumatic disease is presented. The features of this case included the absence of skin manifestations of systemic lupus erythematosus, the occurrence of a tumor at the site of ulcers and trophic disorders on the leg, a long period (6 years) from the onset of a ulcerative defect on the leg to the diagnosis of skin cancer (despite multiple biopsies and consultations of various specialists), as well as the occurrence of a cytokine release syndrome, which directly led to the death of the patient after the first use of the immune checkpoint inhibitors. Possible causes of skin cancer in patients with systemic lupus erythematosus, as well as the features of the cytokine release syndrome after immunotherapy for oncological diseases, are discussed.https://www.medarhive.ru/jour/article/view/1092системная красная волчанкаплоскоклеточный раккожаязвысиндром высвобождения цитокиновингибиторы контрольных точек иммунного ответа |
| spellingShingle | S. V. Topolyanskaya Squamous Cell Skin Carcinoma in Systemic Lupus Erythematosus: Case Report and Literature Review Архивъ внутренней медицины системная красная волчанка плоскоклеточный рак кожа язвы синдром высвобождения цитокинов ингибиторы контрольных точек иммунного ответа |
| title | Squamous Cell Skin Carcinoma in Systemic Lupus Erythematosus: Case Report and Literature Review |
| title_full | Squamous Cell Skin Carcinoma in Systemic Lupus Erythematosus: Case Report and Literature Review |
| title_fullStr | Squamous Cell Skin Carcinoma in Systemic Lupus Erythematosus: Case Report and Literature Review |
| title_full_unstemmed | Squamous Cell Skin Carcinoma in Systemic Lupus Erythematosus: Case Report and Literature Review |
| title_short | Squamous Cell Skin Carcinoma in Systemic Lupus Erythematosus: Case Report and Literature Review |
| title_sort | squamous cell skin carcinoma in systemic lupus erythematosus case report and literature review |
| topic | системная красная волчанка плоскоклеточный рак кожа язвы синдром высвобождения цитокинов ингибиторы контрольных точек иммунного ответа |
| url | https://www.medarhive.ru/jour/article/view/1092 |
| work_keys_str_mv | AT svtopolyanskaya squamouscellskincarcinomainsystemiclupuserythematosuscasereportandliteraturereview |