Development and biophysical characterization of a humanized FSH–blocking monoclonal antibody therapeutic formulated at an ultra-high concentration

Development and biophysical characterization of a humanized FSH–blocking monoclonal antibody therapeutic formulated at an ultra-high concentration

Highly concentrated antibody formulations are oftentimes required for subcutaneous, self-administered biologics. Here, we report the development of a unique formulation for our first-in-class FSH-blocking humanized antibody, MS-Hu6, which we propose to move to the clinic for osteoporosis, obesity, a...

Full description

Bibliographic Details
Main Authors: Satish Rojekar, Anusha R Pallapati, Judit Gimenez-Roig, Funda Korkmaz, Farhath Sultana, Damini Sant, Clement M Haeck, Anne Macdonald, Se-Min Kim, Clifford J Rosen, Orly Barak, Marcia Meseck, John Caminis, Daria Lizneva, Tony Yuen, Mone Zaidi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
drug development
biologics
biotherapeutics
differential fluorescence spectroscopy
accelerated stability
excipient screening
Online Access:https://elifesciences.org/articles/88898

Similar Items

Similar Items