Berberine Induces hERG Channel Deficiency through Trafficking Inhibition

Berberine Induces hERG Channel Deficiency through Trafficking Inhibition

Aims: The human ether-a-go-go-related gene (hERG) encodes the α subunit of the IKr, which plays an essential role in repolarization of action potentials. hERG channels are targeted by various pro-arrhythmic drugs. Berberine (BBR) was previously found to acutely inhibit hERG currents and prolong acti...

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Bibliographic Details
Main Authors:	Kaiping Zhang, Duo Zhi, Ting Huang, Yan Gong, Meng Yan, Chen Liu, Ting Wei, Zengxiang Dong, Baoxin Li, Baofeng Yang
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2014-08-01
Series:	Cellular Physiology and Biochemistry
Subjects:	Berberine hERG Arrhythmia Long QT Syndrome Endoplasmic reticulum stress response Unfolded protein response
Online Access:	http://www.karger.com/Article/FullText/363034

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