Berberine Induces hERG Channel Deficiency through Trafficking Inhibition
Aims: The human ether-a-go-go-related gene (hERG) encodes the α subunit of the IKr, which plays an essential role in repolarization of action potentials. hERG channels are targeted by various pro-arrhythmic drugs. Berberine (BBR) was previously found to acutely inhibit hERG currents and prolong acti...
| Main Authors: | , , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
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Cell Physiol Biochem Press GmbH & Co KG
2014-08-01
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| 丛编: | Cellular Physiology and Biochemistry |
| 主题: | |
| 在线阅读: | http://www.karger.com/Article/FullText/363034 |