ASSOCIATION OF MINERAL ELEMENTS IN THE ATHEROSCLEROTIC PLAQUE IN CORONARY ATHEROSCLEROSIS
Purpose: to determine the content of mineral elements in the homogenates of atherosclerotic plaques of human coronary arteries. Methods: research material – homogenates of samples of atherosclerotic plaques of coronary arteries obtained during coronary bypass surgery. The concentration of chemica...
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| Format: | Article |
| Language: | Russian |
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Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics
2019-03-01
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| Series: | Атеросклероз |
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| Online Access: | https://ateroskleroz.elpub.ru/jour/article/view/171/151 |
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| author | E. Ya. Zhuravskaya T. I. Savchenko O. V. Chankina Ya. V. Polonskaya E. V. Sadowski E. M. Stakhneva Yu. I. Ragino A. M. Chernyavskii |
| author_facet | E. Ya. Zhuravskaya T. I. Savchenko O. V. Chankina Ya. V. Polonskaya E. V. Sadowski E. M. Stakhneva Yu. I. Ragino A. M. Chernyavskii |
| author_sort | E. Ya. Zhuravskaya |
| collection | DOAJ |
| description | Purpose: to determine the content of mineral elements in the homogenates of atherosclerotic plaques of human coronary arteries.
Methods: research material – homogenates of samples of atherosclerotic plaques of coronary arteries obtained during coronary bypass surgery. The concentration of chemical elements Ca, Pb, Fe, Cu, Zn, Br, Sr, Zr in the homogenates of atherosclerotic plaques was determined by x-ray fluorescence analysis using synchrotron radiation (SRXRF).
Results: in all the studied samples the predominant presence of Ca was observed, in stable plaques 1791.93±3042.25 µg/ ml, in unstable atherosclerotic plaques 2024.33±1267.13 µg/ml.Association of Ca with Fe (r = 0.798; p < 0.01), Zn (r = 0.963; p < 0.01) and Sr (r = 0.981; p < 0.01) in the atherosclerotic focus was revealed. No significant difference between the measured elements in stable and unstable plaques was found.
Conclusion: the method x-ray fluorescence analysis using synchrotron radiation revealed some patterns of the mineral composition of an atherosclerotic plaque of a human. The main mineral component of the atherosclerotic plaque is calcium, with a tendency to increase the concentration of the element in the unstable focus. Minor components-iron, zinc, strontium are associated with calcium. In this case, iron tends to reduce the concentration in an unstable atherosclerotic focus, and the concentration of strontium and zinc does not change significantly. |
| first_indexed | 2024-04-11T01:33:03Z |
| format | Article |
| id | doaj.art-dbff62f13f074159a9bcf0c0baa4355e |
| institution | Directory Open Access Journal |
| issn | 2078-256X |
| language | Russian |
| last_indexed | 2024-04-11T01:33:03Z |
| publishDate | 2019-03-01 |
| publisher | Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics |
| record_format | Article |
| series | Атеросклероз |
| spelling | doaj.art-dbff62f13f074159a9bcf0c0baa4355e2023-01-03T09:22:10ZrusSiberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and GeneticsАтеросклероз2078-256X2019-03-011513034https://doi.org/10.15372/ATER20190104ASSOCIATION OF MINERAL ELEMENTS IN THE ATHEROSCLEROTIC PLAQUE IN CORONARY ATHEROSCLEROSISE. Ya. Zhuravskaya0T. I. Savchenko1O. V. Chankina2Ya. V. Polonskaya3E. V. Sadowski4E. M. Stakhneva5Yu. I. Ragino6https://orcid.org/0000-0002-4936-8362A. M. Chernyavskii7Institute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS Russian FederationVoevodsky Institute of Chemical Kinetics and Combustion of SB RAS Russian FederationVoevodsky Institute of Chemical Kinetics and Combustion of SB RAS Russian FederationInstitute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS Russian FederationInstitute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS Russian FederationInstitute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS Russian FederationInstitute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS Russian FederationNational Medical Research Center named academician E.N. Meshalkin of Minzdrav of Russia Russian FederationPurpose: to determine the content of mineral elements in the homogenates of atherosclerotic plaques of human coronary arteries. Methods: research material – homogenates of samples of atherosclerotic plaques of coronary arteries obtained during coronary bypass surgery. The concentration of chemical elements Ca, Pb, Fe, Cu, Zn, Br, Sr, Zr in the homogenates of atherosclerotic plaques was determined by x-ray fluorescence analysis using synchrotron radiation (SRXRF). Results: in all the studied samples the predominant presence of Ca was observed, in stable plaques 1791.93±3042.25 µg/ ml, in unstable atherosclerotic plaques 2024.33±1267.13 µg/ml.Association of Ca with Fe (r = 0.798; p < 0.01), Zn (r = 0.963; p < 0.01) and Sr (r = 0.981; p < 0.01) in the atherosclerotic focus was revealed. No significant difference between the measured elements in stable and unstable plaques was found. Conclusion: the method x-ray fluorescence analysis using synchrotron radiation revealed some patterns of the mineral composition of an atherosclerotic plaque of a human. The main mineral component of the atherosclerotic plaque is calcium, with a tendency to increase the concentration of the element in the unstable focus. Minor components-iron, zinc, strontium are associated with calcium. In this case, iron tends to reduce the concentration in an unstable atherosclerotic focus, and the concentration of strontium and zinc does not change significantly.https://ateroskleroz.elpub.ru/jour/article/view/171/151coronary atherosclerosisatherosclerotic plaquemineral elementscalciumzinc |
| spellingShingle | E. Ya. Zhuravskaya T. I. Savchenko O. V. Chankina Ya. V. Polonskaya E. V. Sadowski E. M. Stakhneva Yu. I. Ragino A. M. Chernyavskii ASSOCIATION OF MINERAL ELEMENTS IN THE ATHEROSCLEROTIC PLAQUE IN CORONARY ATHEROSCLEROSIS Атеросклероз coronary atherosclerosis atherosclerotic plaque mineral elements calcium zinc |
| title | ASSOCIATION OF MINERAL ELEMENTS IN THE ATHEROSCLEROTIC PLAQUE IN CORONARY ATHEROSCLEROSIS |
| title_full | ASSOCIATION OF MINERAL ELEMENTS IN THE ATHEROSCLEROTIC PLAQUE IN CORONARY ATHEROSCLEROSIS |
| title_fullStr | ASSOCIATION OF MINERAL ELEMENTS IN THE ATHEROSCLEROTIC PLAQUE IN CORONARY ATHEROSCLEROSIS |
| title_full_unstemmed | ASSOCIATION OF MINERAL ELEMENTS IN THE ATHEROSCLEROTIC PLAQUE IN CORONARY ATHEROSCLEROSIS |
| title_short | ASSOCIATION OF MINERAL ELEMENTS IN THE ATHEROSCLEROTIC PLAQUE IN CORONARY ATHEROSCLEROSIS |
| title_sort | association of mineral elements in the atherosclerotic plaque in coronary atherosclerosis |
| topic | coronary atherosclerosis atherosclerotic plaque mineral elements calcium zinc |
| url | https://ateroskleroz.elpub.ru/jour/article/view/171/151 |
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