Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells
A biocomposite composed of bacterial cellulose (BC) gel-film and Bacillus subtilis (BS) cells was obtained and characterized with a view to future biomedical applications. The inclusion of functional ingredient (1010/g viable BS cells) in the composite was carried out by their joint aggregation with...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-10-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844019362528 |
| _version_ | 1818537726106927104 |
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| author | I.S. Savitskaya D.H. Shokatayeva A.S. Kistaubayeva L.V. Ignatova I.E. Digel |
| author_facet | I.S. Savitskaya D.H. Shokatayeva A.S. Kistaubayeva L.V. Ignatova I.E. Digel |
| author_sort | I.S. Savitskaya |
| collection | DOAJ |
| description | A biocomposite composed of bacterial cellulose (BC) gel-film and Bacillus subtilis (BS) cells was obtained and characterized with a view to future biomedical applications. The inclusion of functional ingredient (1010/g viable BS cells) in the composite was carried out by their joint aggregation with the BC gel-film. Immobilized BS cells displayed high antagonistic activity towards causative agents of wound infections such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa. Application of the BC/BS-biocomposite for the treatment of excision wounds, performed on laboratory animals, stimulated reparative processes and shortened the healing time. Possible mechanisms of the wound-healing effect of BC/BS gel films are discussed. In this work we claim that the developed BC/BS-material can be positioned as a universal wound coating and sanitary-hygienic product. |
| first_indexed | 2024-12-11T18:54:28Z |
| format | Article |
| id | doaj.art-dbff6dec578a43c7af1a09a8893ee4b9 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-11T18:54:28Z |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-dbff6dec578a43c7af1a09a8893ee4b92022-12-22T00:54:12ZengElsevierHeliyon2405-84402019-10-01510e02592Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cellsI.S. Savitskaya0D.H. Shokatayeva1A.S. Kistaubayeva2L.V. Ignatova3I.E. Digel4Al-Farabi Kazakh National University, Al-Farabi av. 71, Almaty, 050038, KazakhstanAl-Farabi Kazakh National University, Al-Farabi av. 71, Almaty, 050038, KazakhstanAl-Farabi Kazakh National University, Al-Farabi av. 71, Almaty, 050038, Kazakhstan; Corresponding author.Al-Farabi Kazakh National University, Al-Farabi av. 71, Almaty, 050038, KazakhstanAachen University of Applied Sciences, Heinrich-Mußmann-Street 1, Jülich, 52428, GermanyA biocomposite composed of bacterial cellulose (BC) gel-film and Bacillus subtilis (BS) cells was obtained and characterized with a view to future biomedical applications. The inclusion of functional ingredient (1010/g viable BS cells) in the composite was carried out by their joint aggregation with the BC gel-film. Immobilized BS cells displayed high antagonistic activity towards causative agents of wound infections such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa. Application of the BC/BS-biocomposite for the treatment of excision wounds, performed on laboratory animals, stimulated reparative processes and shortened the healing time. Possible mechanisms of the wound-healing effect of BC/BS gel films are discussed. In this work we claim that the developed BC/BS-material can be positioned as a universal wound coating and sanitary-hygienic product.http://www.sciencedirect.com/science/article/pii/S2405844019362528MicrobiologyBiotechnologyMicrobial biotechnologyBacterial celluloseWound healingBacillus subtilis |
| spellingShingle | I.S. Savitskaya D.H. Shokatayeva A.S. Kistaubayeva L.V. Ignatova I.E. Digel Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells Heliyon Microbiology Biotechnology Microbial biotechnology Bacterial cellulose Wound healing Bacillus subtilis |
| title | Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells |
| title_full | Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells |
| title_fullStr | Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells |
| title_full_unstemmed | Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells |
| title_short | Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells |
| title_sort | antimicrobial and wound healing properties of a bacterial cellulose based material containing b subtilis cells |
| topic | Microbiology Biotechnology Microbial biotechnology Bacterial cellulose Wound healing Bacillus subtilis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844019362528 |
| work_keys_str_mv | AT issavitskaya antimicrobialandwoundhealingpropertiesofabacterialcellulosebasedmaterialcontainingbsubtiliscells AT dhshokatayeva antimicrobialandwoundhealingpropertiesofabacterialcellulosebasedmaterialcontainingbsubtiliscells AT askistaubayeva antimicrobialandwoundhealingpropertiesofabacterialcellulosebasedmaterialcontainingbsubtiliscells AT lvignatova antimicrobialandwoundhealingpropertiesofabacterialcellulosebasedmaterialcontainingbsubtiliscells AT iedigel antimicrobialandwoundhealingpropertiesofabacterialcellulosebasedmaterialcontainingbsubtiliscells |