Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation
Female carriers of BRCA1 mutations possess high breast cancer risk, which may reflect deficient growth control of mammary progenitor cells. Here, the authors study progenitor-enriched fractions from these carriers and describe a loss of PLK1-mediated mitotic spindle positioning and an inability of t...
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Bibliographic Details
| Main Authors: |
Zhengcheng He,
Ryan Ghorayeb,
Susanna Tan,
Ke Chen,
Amanda C. Lorentzian,
Jack Bottyan,
Syed Mohammed Musheer Aalam,
Miguel Angel Pujana,
Philipp F. Lange,
Nagarajan Kannan,
Connie J. Eaves,
Christopher A. Maxwell |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-29885-2
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