Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation
Female carriers of BRCA1 mutations possess high breast cancer risk, which may reflect deficient growth control of mammary progenitor cells. Here, the authors study progenitor-enriched fractions from these carriers and describe a loss of PLK1-mediated mitotic spindle positioning and an inability of t...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29885-2 |
| _version_ | 1818522621252206592 |
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| author | Zhengcheng He Ryan Ghorayeb Susanna Tan Ke Chen Amanda C. Lorentzian Jack Bottyan Syed Mohammed Musheer Aalam Miguel Angel Pujana Philipp F. Lange Nagarajan Kannan Connie J. Eaves Christopher A. Maxwell |
| author_facet | Zhengcheng He Ryan Ghorayeb Susanna Tan Ke Chen Amanda C. Lorentzian Jack Bottyan Syed Mohammed Musheer Aalam Miguel Angel Pujana Philipp F. Lange Nagarajan Kannan Connie J. Eaves Christopher A. Maxwell |
| author_sort | Zhengcheng He |
| collection | DOAJ |
| description | Female carriers of BRCA1 mutations possess high breast cancer risk, which may reflect deficient growth control of mammary progenitor cells. Here, the authors study progenitor-enriched fractions from these carriers and describe a loss of PLK1-mediated mitotic spindle positioning and an inability of the progeny to acquire features of mature luminal cells. |
| first_indexed | 2024-12-11T05:35:42Z |
| format | Article |
| id | doaj.art-dc008dd191494a1c87bda1b62ace4d8c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-11T05:35:42Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-dc008dd191494a1c87bda1b62ace4d8c2022-12-22T01:19:17ZengNature PortfolioNature Communications2041-17232022-04-0113111710.1038/s41467-022-29885-2Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientationZhengcheng He0Ryan Ghorayeb1Susanna Tan2Ke Chen3Amanda C. Lorentzian4Jack Bottyan5Syed Mohammed Musheer Aalam6Miguel Angel Pujana7Philipp F. Lange8Nagarajan Kannan9Connie J. Eaves10Christopher A. Maxwell11Department of Pediatrics, University of British ColumbiaDepartment of Pediatrics, University of British ColumbiaTerry Fox Laboratory, British Columbia Cancer Research InstituteDepartment of Pediatrics, University of British ColumbiaDepartment of Pediatrics, University of British ColumbiaDepartment of Pediatrics, University of British ColumbiaDivision of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo ClinicProCURE, Catalan Institute of Oncology, Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), L’Hospitalet del LlobregatDepartment of Pathology and Laboratory Medicine, University of British ColumbiaDivision of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo ClinicTerry Fox Laboratory, British Columbia Cancer Research InstituteDepartment of Pediatrics, University of British ColumbiaFemale carriers of BRCA1 mutations possess high breast cancer risk, which may reflect deficient growth control of mammary progenitor cells. Here, the authors study progenitor-enriched fractions from these carriers and describe a loss of PLK1-mediated mitotic spindle positioning and an inability of the progeny to acquire features of mature luminal cells.https://doi.org/10.1038/s41467-022-29885-2 |
| spellingShingle | Zhengcheng He Ryan Ghorayeb Susanna Tan Ke Chen Amanda C. Lorentzian Jack Bottyan Syed Mohammed Musheer Aalam Miguel Angel Pujana Philipp F. Lange Nagarajan Kannan Connie J. Eaves Christopher A. Maxwell Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation Nature Communications |
| title | Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation |
| title_full | Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation |
| title_fullStr | Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation |
| title_full_unstemmed | Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation |
| title_short | Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation |
| title_sort | pathogenic brca1 variants disrupt plk1 regulation of mitotic spindle orientation |
| url | https://doi.org/10.1038/s41467-022-29885-2 |
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