Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

Female carriers of BRCA1 mutations possess high breast cancer risk, which may reflect deficient growth control of mammary progenitor cells. Here, the authors study progenitor-enriched fractions from these carriers and describe a loss of PLK1-mediated mitotic spindle positioning and an inability of t...

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Bibliographic Details
Main Authors:	Zhengcheng He, Ryan Ghorayeb, Susanna Tan, Ke Chen, Amanda C. Lorentzian, Jack Bottyan, Syed Mohammed Musheer Aalam, Miguel Angel Pujana, Philipp F. Lange, Nagarajan Kannan, Connie J. Eaves, Christopher A. Maxwell
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-022-29885-2

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