The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats
Abstract Introduction Osteoporosis is characterized by deterioration of bone microarchitecture and reduced bone mass and can increase the risk of fracture. To reduce this risk, the aim of this study was to compare the combination effects of olive oil and Lepidium sativum compared to the conventional...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-022-00904-8 |
| _version_ | 1797985511047954432 |
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| author | Dalia M. Badary Heba A. Galal Mahmoud H. Abdelraheim Mohamed I. Sedeek Nesma M. Mohamed Zakaria Y. Abd Elmageed Magda M. Y. Farrag |
| author_facet | Dalia M. Badary Heba A. Galal Mahmoud H. Abdelraheim Mohamed I. Sedeek Nesma M. Mohamed Zakaria Y. Abd Elmageed Magda M. Y. Farrag |
| author_sort | Dalia M. Badary |
| collection | DOAJ |
| description | Abstract Introduction Osteoporosis is characterized by deterioration of bone microarchitecture and reduced bone mass and can increase the risk of fracture. To reduce this risk, the aim of this study was to compare the combination effects of olive oil and Lepidium sativum compared to the conventional drug therapy alendronate. Methods Osteoporosed-induced rat model was established by administration of dexamethasone in female adult albino rats. The serum level of Ca2+, P3+, and osteocalcin was assessed. In addition, histopathological changes and immunohistochemical expression of osteopontin within bone specimens were performed. Results Our results showed that a combination of olive oil and Lepidium sativum had a beneficial therapeutic effect in the treatment of osteoporosis as compared to alendronate therapy. This was demonstrated by increase of serum Ca2+, P3+, and osteocalcin levels in treated compared to control groups. Intriguingly, the highest effect was noticed in rats that received a combination of olive oil and Lepidium sativum compared to the individual treatment. This was reflected by an increase in the cortical bone thickness and a decrease in immunohistochemical expression of osteopontin compared to individual treated groups. Conclusion We concluded that the administration of a combination of olive oil and Lepidium sativum improves bone mineral health and intensity and reduces the risk of osteoporosis in a rat model. |
| first_indexed | 2024-04-11T07:18:15Z |
| format | Article |
| id | doaj.art-dc00fe7cafda44cc8fb1e870cd088b4d |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-04-11T07:18:15Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-dc00fe7cafda44cc8fb1e870cd088b4d2022-12-22T04:37:51ZengBMCEuropean Journal of Medical Research2047-783X2022-11-012711910.1186/s40001-022-00904-8The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in ratsDalia M. Badary0Heba A. Galal1Mahmoud H. Abdelraheim2Mohamed I. Sedeek3Nesma M. Mohamed4Zakaria Y. Abd Elmageed5Magda M. Y. Farrag6Pathology Department, Faculty of Medicine, Assiut UniversityPharmacology Department, Faculty of Veterinary Medicine, Assiut UniversityPharmacology Department, Faculty of Medicine, Assiut UniversityClinical Pathology Department, Faculty of Medicine, Assiut UniversityPharmacognosy Department, Faculty of Pharmacy, Assiut UniversityDepartment of Pharmacology, Edward Via College of Osteopathic Medicine, University of Louisiana at MonroePharmacology Department, Faculty of Medicine, Assiut UniversityAbstract Introduction Osteoporosis is characterized by deterioration of bone microarchitecture and reduced bone mass and can increase the risk of fracture. To reduce this risk, the aim of this study was to compare the combination effects of olive oil and Lepidium sativum compared to the conventional drug therapy alendronate. Methods Osteoporosed-induced rat model was established by administration of dexamethasone in female adult albino rats. The serum level of Ca2+, P3+, and osteocalcin was assessed. In addition, histopathological changes and immunohistochemical expression of osteopontin within bone specimens were performed. Results Our results showed that a combination of olive oil and Lepidium sativum had a beneficial therapeutic effect in the treatment of osteoporosis as compared to alendronate therapy. This was demonstrated by increase of serum Ca2+, P3+, and osteocalcin levels in treated compared to control groups. Intriguingly, the highest effect was noticed in rats that received a combination of olive oil and Lepidium sativum compared to the individual treatment. This was reflected by an increase in the cortical bone thickness and a decrease in immunohistochemical expression of osteopontin compared to individual treated groups. Conclusion We concluded that the administration of a combination of olive oil and Lepidium sativum improves bone mineral health and intensity and reduces the risk of osteoporosis in a rat model.https://doi.org/10.1186/s40001-022-00904-8Osteoporosis, rats, olive oilLepidium sativumAlendronateOsteopontin |
| spellingShingle | Dalia M. Badary Heba A. Galal Mahmoud H. Abdelraheim Mohamed I. Sedeek Nesma M. Mohamed Zakaria Y. Abd Elmageed Magda M. Y. Farrag The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats European Journal of Medical Research Osteoporosis, rats, olive oil Lepidium sativum Alendronate Osteopontin |
| title | The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats |
| title_full | The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats |
| title_fullStr | The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats |
| title_full_unstemmed | The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats |
| title_short | The combination of olive oil and Lepidium sativum improves the deleterious effects resulting from dexamethasone-induced osteoporosis in rats |
| title_sort | combination of olive oil and lepidium sativum improves the deleterious effects resulting from dexamethasone induced osteoporosis in rats |
| topic | Osteoporosis, rats, olive oil Lepidium sativum Alendronate Osteopontin |
| url | https://doi.org/10.1186/s40001-022-00904-8 |
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