Prognosis of cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome.
To examine the prognosis of patients with cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome compared to patients without prior multimorbidity.This multicenter prospective cohort study in Switzerland included 5,635 patients hospitalized with acute coronary syndrome be...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5896917?pdf=render |
| _version_ | 1818448238835924992 |
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| author | Silvia Canivell Olivier Muller Baris Gencer Dik Heg Roland Klingenberg Lorenz Räber David Carballo Christian Matter Thomas Lüscher Stephan Windecker François Mach Nicolas Rodondi David Nanchen |
| author_facet | Silvia Canivell Olivier Muller Baris Gencer Dik Heg Roland Klingenberg Lorenz Räber David Carballo Christian Matter Thomas Lüscher Stephan Windecker François Mach Nicolas Rodondi David Nanchen |
| author_sort | Silvia Canivell |
| collection | DOAJ |
| description | To examine the prognosis of patients with cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome compared to patients without prior multimorbidity.This multicenter prospective cohort study in Switzerland included 5,635 patients hospitalized with acute coronary syndrome between 2009 and 2014, with a one-year follow-up period. We defined cardiovascular and non-cardiovascular multimorbidity as having at least two prior comorbidities before the index hospitalization. Multivariable adjusted Cox proportional models were built to assess the one-year risk of recurrent cardiovascular events, defined as cardiovascular mortality and non-fatal myocardial infarction or stroke. The final model was adjusted for age, gender, body mass index, tobacco consumption, education, and family history of cardiovascular disease, prescription of high-dose statinsat discharge and use of cardiac rehabilitation after discharge.Overall, 3,664 patients (65%) had no multimorbidity, 1,839 (33%) had cardiovascular multimorbidity, 62 (1%) had non-cardiovascular multimorbidity, and 70 (1%) had both cardiovascular and non-cardiovascular multimorbidity. The multivariate risk of recurrent cardiovascular events was increased among patients with cardiovascular multimorbidity (hazard ratio (HR) 2.05, 95% CI: 1.54-2.73, p<0.001) and patients with non-cardiovascular multimorbidity (HR 2.57, 95% CI: 1.04-6.35, p = 0.04) compared to patients without multimorbidity. Patients with cardiovascular and non-cardiovascular multimorbidity had the highest risk of recurrence with a HR of 5.19, 95% CI: 2.79-9.64, p<0.001, compared to patients without multimorbidity.Multimorbidity increased by two-fold the risk of cardiovascular events over the year after an acute coronary syndrome. The magnitude of this increased risk was similar for patients with cardiovascular or non-cardiovascular multimorbidity. |
| first_indexed | 2024-12-14T20:16:21Z |
| format | Article |
| id | doaj.art-dc01af82735144ceadf010ca2df43cdd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T20:16:21Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dc01af82735144ceadf010ca2df43cdd2022-12-21T22:48:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01134e019517410.1371/journal.pone.0195174Prognosis of cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome.Silvia CanivellOlivier MullerBaris GencerDik HegRoland KlingenbergLorenz RäberDavid CarballoChristian MatterThomas LüscherStephan WindeckerFrançois MachNicolas RodondiDavid NanchenTo examine the prognosis of patients with cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome compared to patients without prior multimorbidity.This multicenter prospective cohort study in Switzerland included 5,635 patients hospitalized with acute coronary syndrome between 2009 and 2014, with a one-year follow-up period. We defined cardiovascular and non-cardiovascular multimorbidity as having at least two prior comorbidities before the index hospitalization. Multivariable adjusted Cox proportional models were built to assess the one-year risk of recurrent cardiovascular events, defined as cardiovascular mortality and non-fatal myocardial infarction or stroke. The final model was adjusted for age, gender, body mass index, tobacco consumption, education, and family history of cardiovascular disease, prescription of high-dose statinsat discharge and use of cardiac rehabilitation after discharge.Overall, 3,664 patients (65%) had no multimorbidity, 1,839 (33%) had cardiovascular multimorbidity, 62 (1%) had non-cardiovascular multimorbidity, and 70 (1%) had both cardiovascular and non-cardiovascular multimorbidity. The multivariate risk of recurrent cardiovascular events was increased among patients with cardiovascular multimorbidity (hazard ratio (HR) 2.05, 95% CI: 1.54-2.73, p<0.001) and patients with non-cardiovascular multimorbidity (HR 2.57, 95% CI: 1.04-6.35, p = 0.04) compared to patients without multimorbidity. Patients with cardiovascular and non-cardiovascular multimorbidity had the highest risk of recurrence with a HR of 5.19, 95% CI: 2.79-9.64, p<0.001, compared to patients without multimorbidity.Multimorbidity increased by two-fold the risk of cardiovascular events over the year after an acute coronary syndrome. The magnitude of this increased risk was similar for patients with cardiovascular or non-cardiovascular multimorbidity.http://europepmc.org/articles/PMC5896917?pdf=render |
| spellingShingle | Silvia Canivell Olivier Muller Baris Gencer Dik Heg Roland Klingenberg Lorenz Räber David Carballo Christian Matter Thomas Lüscher Stephan Windecker François Mach Nicolas Rodondi David Nanchen Prognosis of cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome. PLoS ONE |
| title | Prognosis of cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome. |
| title_full | Prognosis of cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome. |
| title_fullStr | Prognosis of cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome. |
| title_full_unstemmed | Prognosis of cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome. |
| title_short | Prognosis of cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome. |
| title_sort | prognosis of cardiovascular and non cardiovascular multimorbidity after acute coronary syndrome |
| url | http://europepmc.org/articles/PMC5896917?pdf=render |
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