High serum alpha-fetoprotein and positive immunohistochemistry of alpha-fetoprotein are related to poor prognosis of gastric cancer with liver metastasis
Abstract Liver metastasis in gastric cancer is incurable. Alpha-fetoprotein-producing gastric cancer has a poor prognosis and is prone to liver metastasis. We investigated the association between preoperative serum alpha-fetoprotein levels, liver metastasis, and expression of primitive enterocyte ph...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-54394-1 |
| _version_ | 1797275240959574016 |
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| author | Yuriko Takayama-Isagawa Kengo Kanetaka Shinichiro Kobayashi Akira Yoneda Shinichiro Ito Susumu Eguchi |
| author_facet | Yuriko Takayama-Isagawa Kengo Kanetaka Shinichiro Kobayashi Akira Yoneda Shinichiro Ito Susumu Eguchi |
| author_sort | Yuriko Takayama-Isagawa |
| collection | DOAJ |
| description | Abstract Liver metastasis in gastric cancer is incurable. Alpha-fetoprotein-producing gastric cancer has a poor prognosis and is prone to liver metastasis. We investigated the association between preoperative serum alpha-fetoprotein levels, liver metastasis, and expression of primitive enterocyte phenotype markers. We reviewed the medical records of 401 patients with gastric cancer who underwent curative surgical resection and immunohistochemically evaluated the primitive phenotype markers. The preoperative serum alpha-fetoprotein levels were elevated and normal in 8 and 393 patients, respectively. Liver metastasis was more frequent in patients with higher preoperative alpha-fetoprotein levels. The 5-year postoperative recurrence-free survival and overall survival rates were significantly worse in patients with higher preoperative serum alpha-fetoprotein levels. Although alpha-fetoprotein and Glypican3 and Spalt-like transcription factor 4 tended to be stained with high preoperative serum alpha-fetoprotein levels, these markers were also positive in some patients with normal alpha-fetoprotein levels. In summary, patients with gastric cancer and high preoperative serum alpha-fetoprotein levels have a poor prognosis and high incidence of liver metastasis. Alpha-fetoprotein can help detect liver metastasis relating to the primitive enterocyte phenotype. |
| first_indexed | 2024-03-07T15:11:31Z |
| format | Article |
| id | doaj.art-dc0398edcfca44fc80895c55355717ee |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:11:31Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-dc0398edcfca44fc80895c55355717ee2024-03-05T18:39:39ZengNature PortfolioScientific Reports2045-23222024-02-011411910.1038/s41598-024-54394-1High serum alpha-fetoprotein and positive immunohistochemistry of alpha-fetoprotein are related to poor prognosis of gastric cancer with liver metastasisYuriko Takayama-Isagawa0Kengo Kanetaka1Shinichiro Kobayashi2Akira Yoneda3Shinichiro Ito4Susumu Eguchi5Department of Pathology, Jichi Medical University HospitalDepartment of Surgery, Nagasaki University Graduate School of Biomedical SciencesDepartment of Surgery, Nagasaki University Graduate School of Biomedical SciencesDepartment of Surgery, Nagasaki University Graduate School of Biomedical SciencesDepartment of Surgery, Nagasaki University Graduate School of Biomedical SciencesDepartment of Surgery, Nagasaki University Graduate School of Biomedical SciencesAbstract Liver metastasis in gastric cancer is incurable. Alpha-fetoprotein-producing gastric cancer has a poor prognosis and is prone to liver metastasis. We investigated the association between preoperative serum alpha-fetoprotein levels, liver metastasis, and expression of primitive enterocyte phenotype markers. We reviewed the medical records of 401 patients with gastric cancer who underwent curative surgical resection and immunohistochemically evaluated the primitive phenotype markers. The preoperative serum alpha-fetoprotein levels were elevated and normal in 8 and 393 patients, respectively. Liver metastasis was more frequent in patients with higher preoperative alpha-fetoprotein levels. The 5-year postoperative recurrence-free survival and overall survival rates were significantly worse in patients with higher preoperative serum alpha-fetoprotein levels. Although alpha-fetoprotein and Glypican3 and Spalt-like transcription factor 4 tended to be stained with high preoperative serum alpha-fetoprotein levels, these markers were also positive in some patients with normal alpha-fetoprotein levels. In summary, patients with gastric cancer and high preoperative serum alpha-fetoprotein levels have a poor prognosis and high incidence of liver metastasis. Alpha-fetoprotein can help detect liver metastasis relating to the primitive enterocyte phenotype.https://doi.org/10.1038/s41598-024-54394-1 |
| spellingShingle | Yuriko Takayama-Isagawa Kengo Kanetaka Shinichiro Kobayashi Akira Yoneda Shinichiro Ito Susumu Eguchi High serum alpha-fetoprotein and positive immunohistochemistry of alpha-fetoprotein are related to poor prognosis of gastric cancer with liver metastasis Scientific Reports |
| title | High serum alpha-fetoprotein and positive immunohistochemistry of alpha-fetoprotein are related to poor prognosis of gastric cancer with liver metastasis |
| title_full | High serum alpha-fetoprotein and positive immunohistochemistry of alpha-fetoprotein are related to poor prognosis of gastric cancer with liver metastasis |
| title_fullStr | High serum alpha-fetoprotein and positive immunohistochemistry of alpha-fetoprotein are related to poor prognosis of gastric cancer with liver metastasis |
| title_full_unstemmed | High serum alpha-fetoprotein and positive immunohistochemistry of alpha-fetoprotein are related to poor prognosis of gastric cancer with liver metastasis |
| title_short | High serum alpha-fetoprotein and positive immunohistochemistry of alpha-fetoprotein are related to poor prognosis of gastric cancer with liver metastasis |
| title_sort | high serum alpha fetoprotein and positive immunohistochemistry of alpha fetoprotein are related to poor prognosis of gastric cancer with liver metastasis |
| url | https://doi.org/10.1038/s41598-024-54394-1 |
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