Effects of loach skin collagen peptides in reducing osteoporosis in mice
The effects of loach skin collagen peptides (LCP) and the combination of LCP and sodium selenite on osteoporosis in mice were investigated. The results showed that the combination of LCP and sodium selenite alleviated mice osteoporosis induced by retinoic acid. It improved bone microarchitecture, in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464620304527 |
| _version_ | 1819292821405827072 |
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| author | Haiying Liu Lu Huang Jing Wang |
| author_facet | Haiying Liu Lu Huang Jing Wang |
| author_sort | Haiying Liu |
| collection | DOAJ |
| description | The effects of loach skin collagen peptides (LCP) and the combination of LCP and sodium selenite on osteoporosis in mice were investigated. The results showed that the combination of LCP and sodium selenite alleviated mice osteoporosis induced by retinoic acid. It improved bone microarchitecture, increased the number and mass of trabecular bone, maintained blood calcium and phosphate balance in mice. The combination of LCP and sodium selenite inhibited the relative mRNA expression levels of Wnt10, β-catenin, osteogenic transcription factors Runx2 and Osterix through the Wnt/β-catenin pathway. The ratio of receptor activator for nuclear factor-kB ligand/Osteoprotegerin (RANKL/OPG) was down-regulated through the OPG/RANKL/NF-kB pathway. Likewise, the relative mRNA expression levels of tumor necrosis factor receptor associated factor 6 (TRAF6), nuclear factor kB (NF-kB) and nuclear factor of activated T-cell (NFATC1) were reduced. This study provides useful information for the use of LCP and sodium selenite in treating and reduction of osteoporosis. |
| first_indexed | 2024-12-24T04:00:37Z |
| format | Article |
| id | doaj.art-dc03c0870cce49eb9b40a6ce526d5e54 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T04:00:37Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-dc03c0870cce49eb9b40a6ce526d5e542022-12-21T17:16:19ZengElsevierJournal of Functional Foods1756-46462020-12-0175104228Effects of loach skin collagen peptides in reducing osteoporosis in miceHaiying Liu0Lu Huang1Jing Wang2State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People’s Republic of China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People’s Republic of China; Corresponding author at: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People’s Republic of China.School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People’s Republic of ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People’s Republic of ChinaThe effects of loach skin collagen peptides (LCP) and the combination of LCP and sodium selenite on osteoporosis in mice were investigated. The results showed that the combination of LCP and sodium selenite alleviated mice osteoporosis induced by retinoic acid. It improved bone microarchitecture, increased the number and mass of trabecular bone, maintained blood calcium and phosphate balance in mice. The combination of LCP and sodium selenite inhibited the relative mRNA expression levels of Wnt10, β-catenin, osteogenic transcription factors Runx2 and Osterix through the Wnt/β-catenin pathway. The ratio of receptor activator for nuclear factor-kB ligand/Osteoprotegerin (RANKL/OPG) was down-regulated through the OPG/RANKL/NF-kB pathway. Likewise, the relative mRNA expression levels of tumor necrosis factor receptor associated factor 6 (TRAF6), nuclear factor kB (NF-kB) and nuclear factor of activated T-cell (NFATC1) were reduced. This study provides useful information for the use of LCP and sodium selenite in treating and reduction of osteoporosis.http://www.sciencedirect.com/science/article/pii/S1756464620304527Collagen peptideOsteoporosisTrabecular bonemicro-CTWnt10 |
| spellingShingle | Haiying Liu Lu Huang Jing Wang Effects of loach skin collagen peptides in reducing osteoporosis in mice Journal of Functional Foods Collagen peptide Osteoporosis Trabecular bone micro-CT Wnt10 |
| title | Effects of loach skin collagen peptides in reducing osteoporosis in mice |
| title_full | Effects of loach skin collagen peptides in reducing osteoporosis in mice |
| title_fullStr | Effects of loach skin collagen peptides in reducing osteoporosis in mice |
| title_full_unstemmed | Effects of loach skin collagen peptides in reducing osteoporosis in mice |
| title_short | Effects of loach skin collagen peptides in reducing osteoporosis in mice |
| title_sort | effects of loach skin collagen peptides in reducing osteoporosis in mice |
| topic | Collagen peptide Osteoporosis Trabecular bone micro-CT Wnt10 |
| url | http://www.sciencedirect.com/science/article/pii/S1756464620304527 |
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