Mitomycin intravascular chemoembolization (MICE) to treat corneal vascularization prior to penetrating keratoplasty
Purpose: To present the clinical outcome of mitomycin intravascular chemoembolization (MICE) as a prophylactic treatment in a patient with HSV-induced corneal neovascularization (NV) before penetrating keratoplasty (PKP). Observations: A 53-year-old male patient presented with a medical history of r...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993624000033 |
| _version_ | 1797301418603839488 |
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| author | Neal Rangu Kamran M. Riaz |
| author_facet | Neal Rangu Kamran M. Riaz |
| author_sort | Neal Rangu |
| collection | DOAJ |
| description | Purpose: To present the clinical outcome of mitomycin intravascular chemoembolization (MICE) as a prophylactic treatment in a patient with HSV-induced corneal neovascularization (NV) before penetrating keratoplasty (PKP). Observations: A 53-year-old male patient presented with a medical history of recurrent herpes simplex virus (HSV) corneal infection. The patient reported worsening visual acuity despite maintenance treatment with systemic antivirals and topical corticosteroids. After the appearance of corneal NV, subconjunctival triamcinolone and bevacizumab injections were given with limited and temporary improvement. Due to worsening corneal NV, MICE was subsequently performed, resulting in the elimination of corneal NV from the visual axis, which allowed for successful PKP 4 months later. Cataract surgery was performed 6 months after PKP. Conclusions and importance: This report describes the potential efficacy of MICE as a prophylactic treatment for corneal NV prior to PKP. |
| first_indexed | 2024-03-07T23:22:18Z |
| format | Article |
| id | doaj.art-dc040ec31ae24a21bffc61c1660c9d72 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-03-07T23:22:18Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-dc040ec31ae24a21bffc61c1660c9d722024-02-21T05:29:20ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362024-03-0133101993Mitomycin intravascular chemoembolization (MICE) to treat corneal vascularization prior to penetrating keratoplastyNeal Rangu0Kamran M. Riaz1Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; College of Medicine, University of Oklahoma, Oklahoma City, OK, USADepartment of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; College of Medicine, University of Oklahoma, Oklahoma City, OK, USA; Corresponding author. Dean A. McGee Eye Institute, University of Oklahoma, 608 Stanton L. Young Blvd, Suite 313, Oklahoma City, OK 73104, USA.Purpose: To present the clinical outcome of mitomycin intravascular chemoembolization (MICE) as a prophylactic treatment in a patient with HSV-induced corneal neovascularization (NV) before penetrating keratoplasty (PKP). Observations: A 53-year-old male patient presented with a medical history of recurrent herpes simplex virus (HSV) corneal infection. The patient reported worsening visual acuity despite maintenance treatment with systemic antivirals and topical corticosteroids. After the appearance of corneal NV, subconjunctival triamcinolone and bevacizumab injections were given with limited and temporary improvement. Due to worsening corneal NV, MICE was subsequently performed, resulting in the elimination of corneal NV from the visual axis, which allowed for successful PKP 4 months later. Cataract surgery was performed 6 months after PKP. Conclusions and importance: This report describes the potential efficacy of MICE as a prophylactic treatment for corneal NV prior to PKP.http://www.sciencedirect.com/science/article/pii/S2451993624000033Mitomycin intravascular chemoembolizationCorneal neovascularizationPenetrating keratoplasty |
| spellingShingle | Neal Rangu Kamran M. Riaz Mitomycin intravascular chemoembolization (MICE) to treat corneal vascularization prior to penetrating keratoplasty American Journal of Ophthalmology Case Reports Mitomycin intravascular chemoembolization Corneal neovascularization Penetrating keratoplasty |
| title | Mitomycin intravascular chemoembolization (MICE) to treat corneal vascularization prior to penetrating keratoplasty |
| title_full | Mitomycin intravascular chemoembolization (MICE) to treat corneal vascularization prior to penetrating keratoplasty |
| title_fullStr | Mitomycin intravascular chemoembolization (MICE) to treat corneal vascularization prior to penetrating keratoplasty |
| title_full_unstemmed | Mitomycin intravascular chemoembolization (MICE) to treat corneal vascularization prior to penetrating keratoplasty |
| title_short | Mitomycin intravascular chemoembolization (MICE) to treat corneal vascularization prior to penetrating keratoplasty |
| title_sort | mitomycin intravascular chemoembolization mice to treat corneal vascularization prior to penetrating keratoplasty |
| topic | Mitomycin intravascular chemoembolization Corneal neovascularization Penetrating keratoplasty |
| url | http://www.sciencedirect.com/science/article/pii/S2451993624000033 |
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