Targeted ablation of signal transducer and activator of transduction 1 alleviates inflammation by microglia/macrophages and promotes long-term recovery after ischemic stroke

Targeted ablation of signal transducer and activator of transduction 1 alleviates inflammation by microglia/macrophages and promotes long-term recovery after ischemic stroke

Abstract Background Brain microglia and macrophages (Mi/MΦ) can shift to a harmful or advantageous phenotype following an ischemic stroke. Identification of key molecules that regulate the transformation of resting Mi/MΦ could aid in the development of innovative therapies for ischemic stroke. The t...

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Bibliographic Details
Main Authors: Wenxuan Han, Hongjian Pu, Sicheng Li, Yaan Liu, Yongfang Zhao, Mingyue Xu, Caixia Chen, Yun Wu, Tuo Yang, Qing Ye, Hong Wang, R. Anne Stetler, Jun Chen, Yejie Shi
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Neuroinflammation
Subjects:
Behavior test
Conditional gene knockout
Neuroinflammation
STAT1
White matter injury
Online Access:https://doi.org/10.1186/s12974-023-02860-4

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