Serotonin system is partially involved in immunomodulation of Nile tilapia (Oreochromis niloticus) immune cells
Serotonin (5-hydroxytryptamine) is a well-known neurotransmitter affecting emotion, behavior, and cognition. Additionally, numerous immunomodulatory functions of serotonin have been discovered in mammals. However, the regulatory role of the serotonin system in fish immunity remains unclear. In this...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.944388/full |
| _version_ | 1828777288317009920 |
|---|---|
| author | Qi Li Baijian Jiang Zhiqiang Zhang Yongxiong Huang Zhou Xu Xinjin Chen Xitan Hou Jia Cai Jia Cai Jia Cai Yu Huang Yu Huang Yu Huang Jichang Jian Jichang Jian Jichang Jian |
| author_facet | Qi Li Baijian Jiang Zhiqiang Zhang Yongxiong Huang Zhou Xu Xinjin Chen Xitan Hou Jia Cai Jia Cai Jia Cai Yu Huang Yu Huang Yu Huang Jichang Jian Jichang Jian Jichang Jian |
| author_sort | Qi Li |
| collection | DOAJ |
| description | Serotonin (5-hydroxytryptamine) is a well-known neurotransmitter affecting emotion, behavior, and cognition. Additionally, numerous immunomodulatory functions of serotonin have been discovered in mammals. However, the regulatory role of the serotonin system in fish immunity remains unclear. In this study, various serotonergic markers in Nile tilapia (Oreochromis niloticus) were identified and characterized. The involvement of the serotonin system during bacterial infection was investigated. Moreover, the expression characteristics and specific functions of serotonergic markers within Nile tilapia immune cells were also assessed. Overall, 22 evolutionarily conserved serotonergic marker genes in Nile tilapia were cloned and characterized. Transcriptional levels of these molecules were most abundant in the brain, and their transcripts were induced during Streptococcus agalactiae infection. Nevertheless, few serotonergic markers exist on Nile tilapia immune cells, and no distinct immunomodulation effect was observed during an immune response. The present study lays a theoretical foundation for further investigation of the immunological mechanisms in fish as well as the evolution of the serotonin system in animals. |
| first_indexed | 2024-12-11T16:18:31Z |
| format | Article |
| id | doaj.art-dc09a1c0d21a443bbb5ecc1281f88185 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T16:18:31Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-dc09a1c0d21a443bbb5ecc1281f881852022-12-22T00:58:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.944388944388Serotonin system is partially involved in immunomodulation of Nile tilapia (Oreochromis niloticus) immune cellsQi Li0Baijian Jiang1Zhiqiang Zhang2Yongxiong Huang3Zhou Xu4Xinjin Chen5Xitan Hou6Jia Cai7Jia Cai8Jia Cai9Yu Huang10Yu Huang11Yu Huang12Jichang Jian13Jichang Jian14Jichang Jian15College of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Zhanjiang, ChinaCollege of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Zhanjiang, ChinaCollege of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Zhanjiang, ChinaCollege of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Zhanjiang, ChinaCollege of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Zhanjiang, ChinaCollege of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Zhanjiang, ChinaInstitute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, ChinaCollege of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Zhanjiang, ChinaLaboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, ChinaGuangdong Provincial Engineering Research Center for Aquatic Animal Health Assessment, Shenzhen, ChinaCollege of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Zhanjiang, ChinaLaboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, ChinaGuangdong Provincial Engineering Research Center for Aquatic Animal Health Assessment, Shenzhen, ChinaCollege of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Zhanjiang, ChinaLaboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, ChinaGuangdong Provincial Engineering Research Center for Aquatic Animal Health Assessment, Shenzhen, ChinaSerotonin (5-hydroxytryptamine) is a well-known neurotransmitter affecting emotion, behavior, and cognition. Additionally, numerous immunomodulatory functions of serotonin have been discovered in mammals. However, the regulatory role of the serotonin system in fish immunity remains unclear. In this study, various serotonergic markers in Nile tilapia (Oreochromis niloticus) were identified and characterized. The involvement of the serotonin system during bacterial infection was investigated. Moreover, the expression characteristics and specific functions of serotonergic markers within Nile tilapia immune cells were also assessed. Overall, 22 evolutionarily conserved serotonergic marker genes in Nile tilapia were cloned and characterized. Transcriptional levels of these molecules were most abundant in the brain, and their transcripts were induced during Streptococcus agalactiae infection. Nevertheless, few serotonergic markers exist on Nile tilapia immune cells, and no distinct immunomodulation effect was observed during an immune response. The present study lays a theoretical foundation for further investigation of the immunological mechanisms in fish as well as the evolution of the serotonin system in animals.https://www.frontiersin.org/articles/10.3389/fimmu.2022.944388/fullNile tilapiaserotoninserotonin receptorsimmunomodulationStreptococcus agalactiae |
| spellingShingle | Qi Li Baijian Jiang Zhiqiang Zhang Yongxiong Huang Zhou Xu Xinjin Chen Xitan Hou Jia Cai Jia Cai Jia Cai Yu Huang Yu Huang Yu Huang Jichang Jian Jichang Jian Jichang Jian Serotonin system is partially involved in immunomodulation of Nile tilapia (Oreochromis niloticus) immune cells Frontiers in Immunology Nile tilapia serotonin serotonin receptors immunomodulation Streptococcus agalactiae |
| title | Serotonin system is partially involved in immunomodulation of Nile tilapia (Oreochromis niloticus) immune cells |
| title_full | Serotonin system is partially involved in immunomodulation of Nile tilapia (Oreochromis niloticus) immune cells |
| title_fullStr | Serotonin system is partially involved in immunomodulation of Nile tilapia (Oreochromis niloticus) immune cells |
| title_full_unstemmed | Serotonin system is partially involved in immunomodulation of Nile tilapia (Oreochromis niloticus) immune cells |
| title_short | Serotonin system is partially involved in immunomodulation of Nile tilapia (Oreochromis niloticus) immune cells |
| title_sort | serotonin system is partially involved in immunomodulation of nile tilapia oreochromis niloticus immune cells |
| topic | Nile tilapia serotonin serotonin receptors immunomodulation Streptococcus agalactiae |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.944388/full |
| work_keys_str_mv | AT qili serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT baijianjiang serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT zhiqiangzhang serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT yongxionghuang serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT zhouxu serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT xinjinchen serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT xitanhou serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT jiacai serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT jiacai serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT jiacai serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT yuhuang serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT yuhuang serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT yuhuang serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT jichangjian serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT jichangjian serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells AT jichangjian serotoninsystemispartiallyinvolvedinimmunomodulationofniletilapiaoreochromisniloticusimmunecells |