SiRNA-mediated ankyrin-G silence modulates the expression of voltage-gated Na channels in murine hippocampal HT22 cells

SiRNA-mediated ankyrin-G silence modulates the expression of voltage-gated Na channels in murine hippocampal HT22 cells

Abstract Background Voltage-gated sodium channels are the targets of many commonly used antiepileptic drugs. NaV1.6, encoded by Scn8a, increased in chronic mesial temporal epilepsy animal models and co-localized with Ankyrin-G, encoded by Ank3. We hypothesized that inhibition of Ank3 transcription b...

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Bibliographic Details
Main Authors: Guanzhong Ni, Xiaoting Hao, Xiaodong Cai, Jiaming Qin, Liemin Zhou, Patrick Kwan, Ziyi Chen
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Acta Epileptologica
Subjects:
Nav1.1
Nav1.6
Ankyrin-G
Hippocampal neurons
HT22
Online Access:http://link.springer.com/article/10.1186/s42494-019-0004-8

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