Dilapan-S versus Phloroglucinol for Cervical Dilatation in Operative Hysteroscopy and Polyp Resection: A Prospective Cohort Study
Background: To compare the effects of Dilapan-S versus phloroglucinol on cervical dilation in hysteroscopic polyp resection. Methods: This prospective, observational study enrolled non-menopausal patients with endometrial polyps who underwent operative hysteroscopy for transcervical polyp resection...
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| Format: | Article |
| Language: | English |
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IMR Press
2023-05-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/50/6/10.31083/j.ceog5006121 |
| _version_ | 1797789246378999808 |
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| author | Ziwei Liu Yahong Xu Aiwen Le |
| author_facet | Ziwei Liu Yahong Xu Aiwen Le |
| author_sort | Ziwei Liu |
| collection | DOAJ |
| description | Background: To compare the effects of Dilapan-S versus phloroglucinol on cervical dilation in hysteroscopic polyp resection. Methods: This prospective, observational study enrolled non-menopausal patients with endometrial polyps who underwent operative hysteroscopy for transcervical polyp resection between October 2021 and October 2022. The patients were given Dilapan-S or phloroglucinol for cervical dilation. The primary outcome was cervical dilation time; secondary outcomes included cervical softening and adverse events. Non-inferiority was prespecified with a margin of 6 seconds. Results: Among 105 included patients, 55 were given phloroglucinol and 50 Dilapan-S. There were no significant differences in age, body mass index (BMI), history of vaginal delivery, hysteroscopic electrotomy, and cervical conization between the two groups (all p > 0.05). The cervical dilation time in the Dilapan-S group was shorter than in the phloroglucinol group (41.74 ± 8.68 s vs. 62.04 ± 9.55 s, non-inferiority p < 0.001). Also, more patients achieved highly effective cervical softening in the Dilapan-S group compared to the phloroglucinol group (44/50 vs. 1/55, p < 0.001). There were 4 cases of diarrhea (p = 0.103), 12 cases of vaginal bleeding (p < 0.001), and 4 cases of abdominal pain in the Dilapan-S group (p = 0.103), and none in the phloroglucinol group. There were also 5 cases of intraoperative water leakage in the phloroglucinol group and 8 cases in the Dilapan-S group (p = 0.283). Conclusions: Dilapan-S is found to be equally effective for cervical dilation as phloroglucinol; however, it is associated with a higher incidence of diarrhea, vaginal bleeding, and abdominal pain complications. |
| first_indexed | 2024-03-13T01:47:01Z |
| format | Article |
| id | doaj.art-dc10aebd462f49168b2fd28ae13bf771 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-03-13T01:47:01Z |
| publishDate | 2023-05-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-dc10aebd462f49168b2fd28ae13bf7712023-07-03T06:41:51ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-05-0150612110.31083/j.ceog5006121S0390-6663(23)02065-1Dilapan-S versus Phloroglucinol for Cervical Dilatation in Operative Hysteroscopy and Polyp Resection: A Prospective Cohort StudyZiwei Liu0Yahong Xu1Aiwen Le2Department of Gynecology, Zunyi Medical University Zhuhai Campus, 519000 Zhuhai, Guangdong, ChinaDepartment of Gynecology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen Nanshan People Hospital and the Sixth Affiliated Hospital of Shenzhen University Health Science Center, 518052 Shenzhen, Guangdong, ChinaDepartment of Gynecology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen Nanshan People Hospital and the Sixth Affiliated Hospital of Shenzhen University Health Science Center, 518052 Shenzhen, Guangdong, ChinaBackground: To compare the effects of Dilapan-S versus phloroglucinol on cervical dilation in hysteroscopic polyp resection. Methods: This prospective, observational study enrolled non-menopausal patients with endometrial polyps who underwent operative hysteroscopy for transcervical polyp resection between October 2021 and October 2022. The patients were given Dilapan-S or phloroglucinol for cervical dilation. The primary outcome was cervical dilation time; secondary outcomes included cervical softening and adverse events. Non-inferiority was prespecified with a margin of 6 seconds. Results: Among 105 included patients, 55 were given phloroglucinol and 50 Dilapan-S. There were no significant differences in age, body mass index (BMI), history of vaginal delivery, hysteroscopic electrotomy, and cervical conization between the two groups (all p > 0.05). The cervical dilation time in the Dilapan-S group was shorter than in the phloroglucinol group (41.74 ± 8.68 s vs. 62.04 ± 9.55 s, non-inferiority p < 0.001). Also, more patients achieved highly effective cervical softening in the Dilapan-S group compared to the phloroglucinol group (44/50 vs. 1/55, p < 0.001). There were 4 cases of diarrhea (p = 0.103), 12 cases of vaginal bleeding (p < 0.001), and 4 cases of abdominal pain in the Dilapan-S group (p = 0.103), and none in the phloroglucinol group. There were also 5 cases of intraoperative water leakage in the phloroglucinol group and 8 cases in the Dilapan-S group (p = 0.283). Conclusions: Dilapan-S is found to be equally effective for cervical dilation as phloroglucinol; however, it is associated with a higher incidence of diarrhea, vaginal bleeding, and abdominal pain complications.https://www.imrpress.com/journal/CEOG/50/6/10.31083/j.ceog5006121dilapanphloroglucinolhysteroscopycervical dilatationprospective study |
| spellingShingle | Ziwei Liu Yahong Xu Aiwen Le Dilapan-S versus Phloroglucinol for Cervical Dilatation in Operative Hysteroscopy and Polyp Resection: A Prospective Cohort Study Clinical and Experimental Obstetrics & Gynecology dilapan phloroglucinol hysteroscopy cervical dilatation prospective study |
| title | Dilapan-S versus Phloroglucinol for Cervical Dilatation in Operative Hysteroscopy and Polyp Resection: A Prospective Cohort Study |
| title_full | Dilapan-S versus Phloroglucinol for Cervical Dilatation in Operative Hysteroscopy and Polyp Resection: A Prospective Cohort Study |
| title_fullStr | Dilapan-S versus Phloroglucinol for Cervical Dilatation in Operative Hysteroscopy and Polyp Resection: A Prospective Cohort Study |
| title_full_unstemmed | Dilapan-S versus Phloroglucinol for Cervical Dilatation in Operative Hysteroscopy and Polyp Resection: A Prospective Cohort Study |
| title_short | Dilapan-S versus Phloroglucinol for Cervical Dilatation in Operative Hysteroscopy and Polyp Resection: A Prospective Cohort Study |
| title_sort | dilapan s versus phloroglucinol for cervical dilatation in operative hysteroscopy and polyp resection a prospective cohort study |
| topic | dilapan phloroglucinol hysteroscopy cervical dilatation prospective study |
| url | https://www.imrpress.com/journal/CEOG/50/6/10.31083/j.ceog5006121 |
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