Translational control mechanisms in cutaneous malignant melanoma: the role of eIF2α

Translational control mechanisms in cutaneous malignant melanoma: the role of eIF2α

Abstract Background Melanoma cells develop adaptive responses in order to cope with particular conditions of tumor microenvironment, characterized by stress conditions and deregulated proliferation. Recently, the interplay between the stress response and the gene expression programs leading to metas...

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Main Authors: Immacolata Maida, Paola Zanna, Stefania Guida, Anna Ferretta, Tiziana Cocco, Luigi Leonardo Palese, Paola Londei, Dario Benelli, Amalia Azzariti, Stefania Tommasi, Michele Guida, Giovanni Pellacani, Gabriella Guida
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Translational Medicine
Subjects:
Metastatic melanoma
eIF2α
BRAF
MiT family
Nuclear peIF2α
Structural analysis
Online Access:http://link.springer.com/article/10.1186/s12967-019-1772-z

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