SARS-CoV-2-infection in the setting of autotransplants for multiple sclerosis
ABSTRACTThe severe adult respiratory syndrome virus type 2 (SARS-CoV-2) related acute respiratory distress syndrome (ARDS) has a strong immunological and inflammatory component; accordingly investigators are employing monoclonal antibodies to ameliorate the virus-induced cytokine storm such as antib...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2022.2164443 |
| _version_ | 1797956983126491136 |
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| author | Juan Carlos Olivares-Gazca Robert Peter Gale Daniela Sánchez-Bonilla Moisés Manuel Gallardo-Pérez Silvia Soto-Olvera Guillermo J. Ruiz-Delgado Guillermo José Ruiz-Argüelles |
| author_facet | Juan Carlos Olivares-Gazca Robert Peter Gale Daniela Sánchez-Bonilla Moisés Manuel Gallardo-Pérez Silvia Soto-Olvera Guillermo J. Ruiz-Delgado Guillermo José Ruiz-Argüelles |
| author_sort | Juan Carlos Olivares-Gazca |
| collection | DOAJ |
| description | ABSTRACTThe severe adult respiratory syndrome virus type 2 (SARS-CoV-2) related acute respiratory distress syndrome (ARDS) has a strong immunological and inflammatory component; accordingly investigators are employing monoclonal antibodies to ameliorate the virus-induced cytokine storm such as antibodies against interleukin 6 (IL-6), tumor necrosis factors alpha (TNF-alpha) and CC chemokine receptor 5 (CCR5) (1). Cyclophosphamide (Cy) has proven its role in various settings including autoimmune diseases, and in the post-haploidentical stem cell transplant setting; Cy depletes cytotoxic and effector T cell populations while relatively sparing the regulatory T cells (Tregs) and could tip the balance away from the overtly pro-inflammatory setting (1). We present here the cases of three persons who were infected by the SARS-CoV-2 virus during the Cy-induced pancytopenia of an autologous hematopoietic stem cell transplantation (HSCT), aimed to down-regulate the immune response in multiple sclerosis (MS) (2). The surprisingly benign course of the COVID-19 in the three cases suggest that the Cy could have had a role in abrogating the inflammatory response in these persons. |
| first_indexed | 2024-04-10T23:57:13Z |
| format | Article |
| id | doaj.art-dc13d71fd7424d9688b74364c950a3b3 |
| institution | Directory Open Access Journal |
| issn | 1607-8454 |
| language | English |
| last_indexed | 2024-04-10T23:57:13Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj.art-dc13d71fd7424d9688b74364c950a3b32023-01-10T10:49:35ZengTaylor & Francis GroupHematology1607-84542023-12-0128110.1080/16078454.2022.2164443SARS-CoV-2-infection in the setting of autotransplants for multiple sclerosisJuan Carlos Olivares-Gazca0Robert Peter Gale1Daniela Sánchez-Bonilla2Moisés Manuel Gallardo-Pérez3Silvia Soto-Olvera4Guillermo J. Ruiz-Delgado5Guillermo José Ruiz-Argüelles6Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoHaematology Research Centre, Department of Immunology and Inflammation, Imperial College London, London, UKCentro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoCentro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoUniversidad Popular Autónoma del Estado de Puebla, Puebla, MéxicoCentro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoCentro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoABSTRACTThe severe adult respiratory syndrome virus type 2 (SARS-CoV-2) related acute respiratory distress syndrome (ARDS) has a strong immunological and inflammatory component; accordingly investigators are employing monoclonal antibodies to ameliorate the virus-induced cytokine storm such as antibodies against interleukin 6 (IL-6), tumor necrosis factors alpha (TNF-alpha) and CC chemokine receptor 5 (CCR5) (1). Cyclophosphamide (Cy) has proven its role in various settings including autoimmune diseases, and in the post-haploidentical stem cell transplant setting; Cy depletes cytotoxic and effector T cell populations while relatively sparing the regulatory T cells (Tregs) and could tip the balance away from the overtly pro-inflammatory setting (1). We present here the cases of three persons who were infected by the SARS-CoV-2 virus during the Cy-induced pancytopenia of an autologous hematopoietic stem cell transplantation (HSCT), aimed to down-regulate the immune response in multiple sclerosis (MS) (2). The surprisingly benign course of the COVID-19 in the three cases suggest that the Cy could have had a role in abrogating the inflammatory response in these persons.https://www.tandfonline.com/doi/10.1080/16078454.2022.2164443Respiratory distress syndromemultiple sclerosisautologous hematopoietic stem cell transplantationSARS-CoV2autoimmune disease |
| spellingShingle | Juan Carlos Olivares-Gazca Robert Peter Gale Daniela Sánchez-Bonilla Moisés Manuel Gallardo-Pérez Silvia Soto-Olvera Guillermo J. Ruiz-Delgado Guillermo José Ruiz-Argüelles SARS-CoV-2-infection in the setting of autotransplants for multiple sclerosis Hematology Respiratory distress syndrome multiple sclerosis autologous hematopoietic stem cell transplantation SARS-CoV2 autoimmune disease |
| title | SARS-CoV-2-infection in the setting of autotransplants for multiple sclerosis |
| title_full | SARS-CoV-2-infection in the setting of autotransplants for multiple sclerosis |
| title_fullStr | SARS-CoV-2-infection in the setting of autotransplants for multiple sclerosis |
| title_full_unstemmed | SARS-CoV-2-infection in the setting of autotransplants for multiple sclerosis |
| title_short | SARS-CoV-2-infection in the setting of autotransplants for multiple sclerosis |
| title_sort | sars cov 2 infection in the setting of autotransplants for multiple sclerosis |
| topic | Respiratory distress syndrome multiple sclerosis autologous hematopoietic stem cell transplantation SARS-CoV2 autoimmune disease |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2022.2164443 |
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