Dynamics of Melanoma-Associated Epitope-Specific CD8+ T Cells in the Blood Correlate With Clinical Outcome Under PD-1 Blockade

Dynamics of Melanoma-Associated Epitope-Specific CD8+ T Cells in the Blood Correlate With Clinical Outcome Under PD-1 Blockade

Immune checkpoint blockade (ICB) is standard-of-care for patients with metastatic melanoma. It may re-invigorate T cells recognizing tumors, and several tumor antigens have been identified as potential targets. However, little is known about the dynamics of tumor antigen-specific T cells in the circ...

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Bibliographic Details
Main Authors: Andrea Gaißler, Trine Sundebo Meldgaard, Christina Heeke, Sepideh Babaei, Siri Amanda Tvingsholm, Jonas Bochem, Janine Spreuer, Teresa Amaral, Nikolaus Benjamin Wagner, Reinhild Klein, Friedegund Meier, Claus Garbe, Thomas K. Eigentler, Graham Pawelec, Manfred Claassen, Benjamin Weide, Sine Reker Hadrup, Kilian Wistuba-Hamprecht
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
T cells
checkpoint blockade
melanoma
melanoma-associated antigen
regression analysis
dextramer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.906352/full

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