From liver biopsy to non-invasive markers in evaluating fibrosis in chronic liver disease
Chronic liver disease is a late stage of progressive hepatic fibrosis. It consists of functional and structural disruptions in most chronic liver diseases. An accurate diagnosis allows us to establish the degree of fibrosis and the stage of the disease, the prognosis of the patient and to predict a...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Carol Davila University of Medicine and Pharmacy Publishing House
2015-08-01
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| Series: | Romanian Journal of Military Medicine |
| Subjects: | |
| Online Access: | http://revistamedicinamilitara.ro/wp-content/uploads/2016/04/2015-02-full.7-14.pdf |
| _version_ | 1811272966951927808 |
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| author | Cătălina Diaconu Florentina Ioniță Radu Mariana Jinga Petruț Nuță Săndica Bucurică Bogdan Macadon Mihăiță Pătrășescu Andrada Popescu Vasile Balaban Laura Voicu Daniel O. Costache Raluca S. Costache |
| author_facet | Cătălina Diaconu Florentina Ioniță Radu Mariana Jinga Petruț Nuță Săndica Bucurică Bogdan Macadon Mihăiță Pătrășescu Andrada Popescu Vasile Balaban Laura Voicu Daniel O. Costache Raluca S. Costache |
| author_sort | Cătălina Diaconu |
| collection | DOAJ |
| description | Chronic liver disease is a late stage of progressive hepatic fibrosis. It consists of functional and structural disruptions in most chronic liver diseases. An accurate diagnosis allows us
to establish the degree of fibrosis and the stage of the disease, the prognosis of the patient and to predict a treatment response. Despite the fact that liver biopsy is considered a gold standard, noninvasive methods for diagnosing liver fibrosis have gained more and more importance. Whether we talk about serum biomarkers or imagistic methods from transient elastography to 3-D magnetic resonance elastography, the question remains: are these useful or useless? Serum biomarkers represent blood components that can reflect liver histological changes, thus they can monitor the continuous process of fibrosis. These can be subcategorized in direct (that show extracellular matrix turnover) and indirect markers (that reflect disturbances in the hepatic
function). However these markers alone are not as accurate in the staging of fibrosis, only help differentiate patients without or with low grade of fibrosis from those with significant fibrosis and
cannot be considered alone in the diagnosis of liver fibrosis. Imagistic methods include: ultrasound-based transient elastography, magnetic resonance elastography (MRE), 2D-shear wave elastography, acoustic radiation impulse imaging (ARFI) and cross sectional imaging, the first being the most used. Using a combination of non-invasive tools allows us to diminish the number of patients in need of liver biopsy. However, the patient must always be informed of the advantages and disadvantages of each method and its limitations. |
| first_indexed | 2024-04-12T22:49:38Z |
| format | Article |
| id | doaj.art-dc1c9c96b2454aabae4c1f048a1b8d65 |
| institution | Directory Open Access Journal |
| issn | 1222-5126 2501-2312 |
| language | English |
| last_indexed | 2024-04-12T22:49:38Z |
| publishDate | 2015-08-01 |
| publisher | Carol Davila University of Medicine and Pharmacy Publishing House |
| record_format | Article |
| series | Romanian Journal of Military Medicine |
| spelling | doaj.art-dc1c9c96b2454aabae4c1f048a1b8d652022-12-22T03:13:25ZengCarol Davila University of Medicine and Pharmacy Publishing HouseRomanian Journal of Military Medicine1222-51262501-23122015-08-01CXVIII2512From liver biopsy to non-invasive markers in evaluating fibrosis in chronic liver diseaseCătălina Diaconu0Florentina Ioniță Radu1Mariana Jinga2Petruț Nuță3Săndica Bucurică4Bogdan Macadon5Mihăiță Pătrășescu6Andrada Popescu7Vasile Balaban8Laura Voicu9Daniel O. Costache10Raluca S. Costache11Carol Davila Central Emergency Military Hospital, BucharestCarol Davila Central Emergency Military Hospital, BucharestCarol Davila Central Emergency Military Hospital, BucharestCarol Davila Central Emergency Military Hospital, BucharestCarol Davila Central Emergency Military Hospital, BucharestCarol Davila Central Emergency Military Hospital, BucharestCarol Davila Central Emergency Military Hospital, BucharestCarol Davila Central Emergency Military Hospital, BucharestCarol Davila Central Emergency Military Hospital, BucharestCarol Davila Central Emergency Military Hospital, BucharestCarol Davila Central Emergency Military Hospital, BucharestCarol Davila Central Emergency Military Hospital, BucharestChronic liver disease is a late stage of progressive hepatic fibrosis. It consists of functional and structural disruptions in most chronic liver diseases. An accurate diagnosis allows us to establish the degree of fibrosis and the stage of the disease, the prognosis of the patient and to predict a treatment response. Despite the fact that liver biopsy is considered a gold standard, noninvasive methods for diagnosing liver fibrosis have gained more and more importance. Whether we talk about serum biomarkers or imagistic methods from transient elastography to 3-D magnetic resonance elastography, the question remains: are these useful or useless? Serum biomarkers represent blood components that can reflect liver histological changes, thus they can monitor the continuous process of fibrosis. These can be subcategorized in direct (that show extracellular matrix turnover) and indirect markers (that reflect disturbances in the hepatic function). However these markers alone are not as accurate in the staging of fibrosis, only help differentiate patients without or with low grade of fibrosis from those with significant fibrosis and cannot be considered alone in the diagnosis of liver fibrosis. Imagistic methods include: ultrasound-based transient elastography, magnetic resonance elastography (MRE), 2D-shear wave elastography, acoustic radiation impulse imaging (ARFI) and cross sectional imaging, the first being the most used. Using a combination of non-invasive tools allows us to diminish the number of patients in need of liver biopsy. However, the patient must always be informed of the advantages and disadvantages of each method and its limitations.http://revistamedicinamilitara.ro/wp-content/uploads/2016/04/2015-02-full.7-14.pdffibrosisbiopsyelastographybiomarkers |
| spellingShingle | Cătălina Diaconu Florentina Ioniță Radu Mariana Jinga Petruț Nuță Săndica Bucurică Bogdan Macadon Mihăiță Pătrășescu Andrada Popescu Vasile Balaban Laura Voicu Daniel O. Costache Raluca S. Costache From liver biopsy to non-invasive markers in evaluating fibrosis in chronic liver disease Romanian Journal of Military Medicine fibrosis biopsy elastography biomarkers |
| title | From liver biopsy to non-invasive markers in evaluating fibrosis in chronic liver disease |
| title_full | From liver biopsy to non-invasive markers in evaluating fibrosis in chronic liver disease |
| title_fullStr | From liver biopsy to non-invasive markers in evaluating fibrosis in chronic liver disease |
| title_full_unstemmed | From liver biopsy to non-invasive markers in evaluating fibrosis in chronic liver disease |
| title_short | From liver biopsy to non-invasive markers in evaluating fibrosis in chronic liver disease |
| title_sort | from liver biopsy to non invasive markers in evaluating fibrosis in chronic liver disease |
| topic | fibrosis biopsy elastography biomarkers |
| url | http://revistamedicinamilitara.ro/wp-content/uploads/2016/04/2015-02-full.7-14.pdf |
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