First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran
Background and Purpose: Herein, we report the first case of fungal keratitis due to Aspergillus minisclerotigenes in a 68-year-old rural woman admitted to the Ophthalmology Center of Khatam-Al-Anbia Hospital in Mashhad, northeast of Iran.<br /> <br /> Case report: The patient presented w...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2019-06-01
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| Series: | Current Medical Mycology |
| Subjects: | |
| Online Access: | http://cmm.mazums.ac.ir/article_90419_b966252640ee2745ebfe0e5d4dd7ec08.pdf |
| _version_ | 1818998349605371904 |
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| author | Mohammad Javad Najafzadeh Mahmoud Karimizadeh Esfahani Alireza Eslampoor Somayeh Dolatabadi Jos Houbraken |
| author_facet | Mohammad Javad Najafzadeh Mahmoud Karimizadeh Esfahani Alireza Eslampoor Somayeh Dolatabadi Jos Houbraken |
| author_sort | Mohammad Javad Najafzadeh |
| collection | DOAJ |
| description | Background and Purpose: Herein, we report the first case of fungal keratitis due to Aspergillus minisclerotigenes in a 68-year-old rural woman admitted to the Ophthalmology Center of Khatam-Al-Anbia Hospital in Mashhad, northeast of Iran.<br /> <br /> Case report: The patient presented with severe pain, burning, foreign body sensation, and reduced vision in her right eye. She had long-term uncontrolled diabetes and was not able to close her eye due to an anatomical problem with the eyelid. The cornea smear sample was cultured, and the fungus was initially identified as Aspergillus flavus. The isolated strain was further identified by sequencing a part of the calmodulin gene as A. minisclerotigenes. The patient did not respond to any antifungal treatments (e.g., amphotericin B and voriconazole drops, and fluconazole 300 mg/day); therefore, she was eventually subjected to corneal transplantation surgery.<br /> <br /> Conclusion: Fungal keratitis can be caused by the less common species. The reliable identification of the causative agents can be accomplished by the implementation of molecular methods. |
| first_indexed | 2024-12-20T22:00:07Z |
| format | Article |
| id | doaj.art-dc209fce289443e89b4e356ff1e30665 |
| institution | Directory Open Access Journal |
| issn | 2423-3439 2423-3420 |
| language | English |
| last_indexed | 2024-12-20T22:00:07Z |
| publishDate | 2019-06-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Current Medical Mycology |
| spelling | doaj.art-dc209fce289443e89b4e356ff1e306652022-12-21T19:25:21ZengMazandaran University of Medical SciencesCurrent Medical Mycology2423-34392423-34202019-06-0152454810.18502/cmm.5.2.116290419First case of fungal keratitis due to Aspergillus minisclerotigenes in IranMohammad Javad Najafzadeh0Mahmoud Karimizadeh Esfahani1Alireza Eslampoor2Somayeh Dolatabadi3Jos Houbraken4Mashhad University of Medical SciencesDepartment of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranEye Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranFaculty of Engineering, Sabzevar University of New Technology, Sabzevar, IranWesterdijk Fungal Biodiversity Institute, Utrecht, the NetherlandsBackground and Purpose: Herein, we report the first case of fungal keratitis due to Aspergillus minisclerotigenes in a 68-year-old rural woman admitted to the Ophthalmology Center of Khatam-Al-Anbia Hospital in Mashhad, northeast of Iran.<br /> <br /> Case report: The patient presented with severe pain, burning, foreign body sensation, and reduced vision in her right eye. She had long-term uncontrolled diabetes and was not able to close her eye due to an anatomical problem with the eyelid. The cornea smear sample was cultured, and the fungus was initially identified as Aspergillus flavus. The isolated strain was further identified by sequencing a part of the calmodulin gene as A. minisclerotigenes. The patient did not respond to any antifungal treatments (e.g., amphotericin B and voriconazole drops, and fluconazole 300 mg/day); therefore, she was eventually subjected to corneal transplantation surgery.<br /> <br /> Conclusion: Fungal keratitis can be caused by the less common species. The reliable identification of the causative agents can be accomplished by the implementation of molecular methods.http://cmm.mazums.ac.ir/article_90419_b966252640ee2745ebfe0e5d4dd7ec08.pdfaspergillus minisclerotigenesfungal keratitisiran |
| spellingShingle | Mohammad Javad Najafzadeh Mahmoud Karimizadeh Esfahani Alireza Eslampoor Somayeh Dolatabadi Jos Houbraken First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran Current Medical Mycology aspergillus minisclerotigenes fungal keratitis iran |
| title | First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran |
| title_full | First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran |
| title_fullStr | First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran |
| title_full_unstemmed | First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran |
| title_short | First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran |
| title_sort | first case of fungal keratitis due to aspergillus minisclerotigenes in iran |
| topic | aspergillus minisclerotigenes fungal keratitis iran |
| url | http://cmm.mazums.ac.ir/article_90419_b966252640ee2745ebfe0e5d4dd7ec08.pdf |
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