CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study
Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) andCCR5-Δ32 (rs333) polymorphisms with susceptibility to develop cervical lesion (CIN and CC)...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2016-03-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000300174&lng=en&tlng=en |
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| author | Erinaldo Ubirajara Damasceno dos Santos Géssica Dayane Cordeiro de Lima Micheline de Lucena Oliveira Sandra de Andrade Heráclio Hildson Dornelas Angelo da Silva Sergio Crovella Maria de Mascena Diniz Maia Paulo Roberto Eleutério de Souza/ |
| author_facet | Erinaldo Ubirajara Damasceno dos Santos Géssica Dayane Cordeiro de Lima Micheline de Lucena Oliveira Sandra de Andrade Heráclio Hildson Dornelas Angelo da Silva Sergio Crovella Maria de Mascena Diniz Maia Paulo Roberto Eleutério de Souza/ |
| author_sort | Erinaldo Ubirajara Damasceno dos Santos |
| collection | DOAJ |
| description | Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) andCCR5-Δ32 (rs333) polymorphisms with susceptibility to develop cervical lesion (CIN and CC) in a Brazilian population. The genotyping of 139 women with cervical lesions and 151 women without cervical lesions for the CCR2-64I and CCR5-Δ32 polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism. The individuals carrying heterozygous or homozygous genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk for cervical lesion [odds ratio (OR) = 0.37, p = 0.0008)]. The same was observed for the A allele (OR = 0.39, p = 0.0002), while no association was detected (p > 0.05) with CCR5-Δ32 polymorphism. Regarding the human papillomavirus (HPV) type, patients carrying the CCR2-64Ipolymorphism were protected against infection by HPV type 16 (OR = 0.35, p = 0.0184). In summary, our study showed a protective effect ofCCR2-64I rs1799864 polymorphism against the development of cervical lesions (CIN and CC) and in the susceptibility of HPV 16 infection. |
| first_indexed | 2024-03-12T07:24:39Z |
| format | Article |
| id | doaj.art-dc21cb0202744a4b84f093fad8b008df |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:24:39Z |
| publishDate | 2016-03-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-dc21cb0202744a4b84f093fad8b008df2023-09-02T22:14:54ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602016-03-01111317418010.1590/0074-02760150367S0074-02762016000300174CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control studyErinaldo Ubirajara Damasceno dos SantosGéssica Dayane Cordeiro de LimaMicheline de Lucena OliveiraSandra de Andrade HeráclioHildson Dornelas Angelo da SilvaSergio CrovellaMaria de Mascena Diniz MaiaPaulo Roberto Eleutério de Souza/Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) andCCR5-Δ32 (rs333) polymorphisms with susceptibility to develop cervical lesion (CIN and CC) in a Brazilian population. The genotyping of 139 women with cervical lesions and 151 women without cervical lesions for the CCR2-64I and CCR5-Δ32 polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism. The individuals carrying heterozygous or homozygous genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk for cervical lesion [odds ratio (OR) = 0.37, p = 0.0008)]. The same was observed for the A allele (OR = 0.39, p = 0.0002), while no association was detected (p > 0.05) with CCR5-Δ32 polymorphism. Regarding the human papillomavirus (HPV) type, patients carrying the CCR2-64Ipolymorphism were protected against infection by HPV type 16 (OR = 0.35, p = 0.0184). In summary, our study showed a protective effect ofCCR2-64I rs1799864 polymorphism against the development of cervical lesions (CIN and CC) and in the susceptibility of HPV 16 infection.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000300174&lng=en&tlng=enchemokine receptorscervical intraepithelial neoplasiacervical cancersingle nucleotide polymorphism |
| spellingShingle | Erinaldo Ubirajara Damasceno dos Santos Géssica Dayane Cordeiro de Lima Micheline de Lucena Oliveira Sandra de Andrade Heráclio Hildson Dornelas Angelo da Silva Sergio Crovella Maria de Mascena Diniz Maia Paulo Roberto Eleutério de Souza/ CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study Memorias do Instituto Oswaldo Cruz chemokine receptors cervical intraepithelial neoplasia cervical cancer single nucleotide polymorphism |
| title | CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study |
| title_full | CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study |
| title_fullStr | CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study |
| title_full_unstemmed | CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study |
| title_short | CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study |
| title_sort | ccr2 and ccr5 genes polymorphisms in women with cervical lesions from pernambuco northeast region of brazil a case control study |
| topic | chemokine receptors cervical intraepithelial neoplasia cervical cancer single nucleotide polymorphism |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000300174&lng=en&tlng=en |
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