Glial Fibrillary Acidic Protein Levels in Post-Stroke Depression: A Prospective Ischemic Stroke Cohort
Wanying Shan,1,* Jie Zhao,2,* Chunfang Qiu,1 Guoli Xu,1 Jie Feng1 1Department of Neurology, Suzhou Ninth People’s Hospital, Soochow University, Suzhou, Jiangsu, 215200, People’s Republic of China; 2Department of Gerontology, Suzhou Ninth People’s Hospital, Soochow University, Suzhou,...
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| Format: | Article |
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Dove Medical Press
2023-10-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/glial-fibrillary-acidic-protein-levels-in-post-stroke-depression-a-pro-peer-reviewed-fulltext-article-NDT |
| _version_ | 1797655744493912064 |
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| author | Shan W Zhao J Qiu C Xu G Feng J |
| author_facet | Shan W Zhao J Qiu C Xu G Feng J |
| author_sort | Shan W |
| collection | DOAJ |
| description | Wanying Shan,1,* Jie Zhao,2,* Chunfang Qiu,1 Guoli Xu,1 Jie Feng1 1Department of Neurology, Suzhou Ninth People’s Hospital, Soochow University, Suzhou, Jiangsu, 215200, People’s Republic of China; 2Department of Gerontology, Suzhou Ninth People’s Hospital, Soochow University, Suzhou, Jiangsu, 215200, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Feng, Department of Neurology, Suzhou Ninth People’s Hospital, Soochow University, No. 2666 Ludang Road, Suzhou, Jiangsu, 215200, People’s Republic of China, Tel/Fax +86 051282881332, Email fengjie6769@163.comBackground and Purpose: Increased glial fibrillary acidic protein (GFAP) levels were found in cerebrovascular disease patients. The pathogenesis of depression after ischemic stroke remains largely unknown. Here, we aim to determine whether GFAP concentrations were associated with post-stroke depression (PSD) at 3 months.Methods: From March 2022 to September 2022, patients with first-ever ischemic stroke were prospectively recruited. GFAP concentrations were detected within 24 h using an enzyme-linked immunosorbent assay. The PSD was defined as a Hamilton Depression Rating Scale 24-Item score ≥ 8.Results: A total of 206 subjects with ischemic stroke (mean age: 63.6 years; 49.0% female) were enrolled. During the 90-day follow-up, 57 participants (27.7%) were observed in PSD. The median serum GFAP concentrations were 0.67 ng/mL. After adjustment for the covariates, higher increased GFAP levels were associated with increased risk of PSD (odds ratio [OR], 7.12; 95% confidence interval [CI], 3.29– 15.44; P < 0.001). Also, the multivariate-adjusted OR of PSD associated with the fourth quartile of GFAP was 10.89 (95% CI, 3.53– 33.60; P < 0.001) compared with the first quartile. Furthermore, the restricted cubic spline confirmed a linear association between GFAP and the risk of PSD (P for linearity < 0.001).Conclusion: Our results indicated that increased circulating GFAP concentrations were significantly correlated with the risk of PSD at 3 months. Measuring the GFAP levels after ischemic stroke may add some values for the risk stratifying of PSD.Keywords: post-stroke depression, ischemic stroke, prognosis, glial fibrillary acidic protein, prospective study |
| first_indexed | 2024-03-11T17:19:05Z |
| format | Article |
| id | doaj.art-dc2353a215c6456b8e9cada64e835b76 |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-03-11T17:19:05Z |
| publishDate | 2023-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-dc2353a215c6456b8e9cada64e835b762023-10-19T17:10:55ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212023-10-01Volume 192171217887459Glial Fibrillary Acidic Protein Levels in Post-Stroke Depression: A Prospective Ischemic Stroke CohortShan WZhao JQiu CXu GFeng JWanying Shan,1,* Jie Zhao,2,* Chunfang Qiu,1 Guoli Xu,1 Jie Feng1 1Department of Neurology, Suzhou Ninth People’s Hospital, Soochow University, Suzhou, Jiangsu, 215200, People’s Republic of China; 2Department of Gerontology, Suzhou Ninth People’s Hospital, Soochow University, Suzhou, Jiangsu, 215200, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Feng, Department of Neurology, Suzhou Ninth People’s Hospital, Soochow University, No. 2666 Ludang Road, Suzhou, Jiangsu, 215200, People’s Republic of China, Tel/Fax +86 051282881332, Email fengjie6769@163.comBackground and Purpose: Increased glial fibrillary acidic protein (GFAP) levels were found in cerebrovascular disease patients. The pathogenesis of depression after ischemic stroke remains largely unknown. Here, we aim to determine whether GFAP concentrations were associated with post-stroke depression (PSD) at 3 months.Methods: From March 2022 to September 2022, patients with first-ever ischemic stroke were prospectively recruited. GFAP concentrations were detected within 24 h using an enzyme-linked immunosorbent assay. The PSD was defined as a Hamilton Depression Rating Scale 24-Item score ≥ 8.Results: A total of 206 subjects with ischemic stroke (mean age: 63.6 years; 49.0% female) were enrolled. During the 90-day follow-up, 57 participants (27.7%) were observed in PSD. The median serum GFAP concentrations were 0.67 ng/mL. After adjustment for the covariates, higher increased GFAP levels were associated with increased risk of PSD (odds ratio [OR], 7.12; 95% confidence interval [CI], 3.29– 15.44; P < 0.001). Also, the multivariate-adjusted OR of PSD associated with the fourth quartile of GFAP was 10.89 (95% CI, 3.53– 33.60; P < 0.001) compared with the first quartile. Furthermore, the restricted cubic spline confirmed a linear association between GFAP and the risk of PSD (P for linearity < 0.001).Conclusion: Our results indicated that increased circulating GFAP concentrations were significantly correlated with the risk of PSD at 3 months. Measuring the GFAP levels after ischemic stroke may add some values for the risk stratifying of PSD.Keywords: post-stroke depression, ischemic stroke, prognosis, glial fibrillary acidic protein, prospective studyhttps://www.dovepress.com/glial-fibrillary-acidic-protein-levels-in-post-stroke-depression-a-pro-peer-reviewed-fulltext-article-NDTpost-stroke depressionischemic strokeprognosisglial fibrillary acidic proteinprospective study. |
| spellingShingle | Shan W Zhao J Qiu C Xu G Feng J Glial Fibrillary Acidic Protein Levels in Post-Stroke Depression: A Prospective Ischemic Stroke Cohort Neuropsychiatric Disease and Treatment post-stroke depression ischemic stroke prognosis glial fibrillary acidic protein prospective study. |
| title | Glial Fibrillary Acidic Protein Levels in Post-Stroke Depression: A Prospective Ischemic Stroke Cohort |
| title_full | Glial Fibrillary Acidic Protein Levels in Post-Stroke Depression: A Prospective Ischemic Stroke Cohort |
| title_fullStr | Glial Fibrillary Acidic Protein Levels in Post-Stroke Depression: A Prospective Ischemic Stroke Cohort |
| title_full_unstemmed | Glial Fibrillary Acidic Protein Levels in Post-Stroke Depression: A Prospective Ischemic Stroke Cohort |
| title_short | Glial Fibrillary Acidic Protein Levels in Post-Stroke Depression: A Prospective Ischemic Stroke Cohort |
| title_sort | glial fibrillary acidic protein levels in post stroke depression a prospective ischemic stroke cohort |
| topic | post-stroke depression ischemic stroke prognosis glial fibrillary acidic protein prospective study. |
| url | https://www.dovepress.com/glial-fibrillary-acidic-protein-levels-in-post-stroke-depression-a-pro-peer-reviewed-fulltext-article-NDT |
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