Knee osteoarthrosis secondary to ochronosis -clinical case,
Alkaptonuria is a rare metabolic disease in which a deficiency of the enzyme homogentisate dioxygenase causes an accumulation of homogentisic acid. Ochronosis consists of excessive deposition of homogentisic acid in the connective tissue and presents as a chestnut brown or black pigmentation. With a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Ortopedia e Traumatologia
2014-12-01
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| Series: | Revista Brasileira de Ortopedia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162014000600675&lng=en&tlng=en |
| _version_ | 1797330368036077568 |
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| author | Andreia Maria da Silva Martins Ferreira Filipe Lima Santos André Miguel Castro Costa Bruno Miguel Pereira Barbosa Rui Miguel Reis Rocha Joaquim Fernando Fontes Lebre |
| author_facet | Andreia Maria da Silva Martins Ferreira Filipe Lima Santos André Miguel Castro Costa Bruno Miguel Pereira Barbosa Rui Miguel Reis Rocha Joaquim Fernando Fontes Lebre |
| author_sort | Andreia Maria da Silva Martins Ferreira |
| collection | DOAJ |
| description | Alkaptonuria is a rare metabolic disease in which a deficiency of the enzyme homogentisate dioxygenase causes an accumulation of homogentisic acid. Ochronosis consists of excessive deposition of homogentisic acid in the connective tissue and presents as a chestnut brown or black pigmentation. With aging, the accumulation of pigments from homogentisic acid in the joints causes osteoarthrosis. There is no specific treatment for the disease and the approach is symptomatic. Arthroplasty is the solution for severe cases of osteoarthrosis caused by this pathological condition and presents results comparable to those from patients with primary osteoarthrosis. Here, the case of a 67-year-old patient who underwent several arthroplasty procedures because of osteoarthrosis caused by this rare pathological condition is presented. The last surgical intervention consisted of total right knee arthroplasty. |
| first_indexed | 2024-03-08T07:17:55Z |
| format | Article |
| id | doaj.art-dc238b74e354470d92830dbd2ca44f01 |
| institution | Directory Open Access Journal |
| issn | 1982-4378 |
| language | English |
| last_indexed | 2024-03-08T07:17:55Z |
| publishDate | 2014-12-01 |
| publisher | Sociedade Brasileira de Ortopedia e Traumatologia |
| record_format | Article |
| series | Revista Brasileira de Ortopedia |
| spelling | doaj.art-dc238b74e354470d92830dbd2ca44f012024-02-03T00:16:03ZengSociedade Brasileira de Ortopedia e TraumatologiaRevista Brasileira de Ortopedia1982-43782014-12-0149667568010.1016/j.rboe.2013.11.001S0102-36162014000600675Knee osteoarthrosis secondary to ochronosis -clinical case,Andreia Maria da Silva Martins FerreiraFilipe Lima SantosAndré Miguel Castro CostaBruno Miguel Pereira BarbosaRui Miguel Reis RochaJoaquim Fernando Fontes LebreAlkaptonuria is a rare metabolic disease in which a deficiency of the enzyme homogentisate dioxygenase causes an accumulation of homogentisic acid. Ochronosis consists of excessive deposition of homogentisic acid in the connective tissue and presents as a chestnut brown or black pigmentation. With aging, the accumulation of pigments from homogentisic acid in the joints causes osteoarthrosis. There is no specific treatment for the disease and the approach is symptomatic. Arthroplasty is the solution for severe cases of osteoarthrosis caused by this pathological condition and presents results comparable to those from patients with primary osteoarthrosis. Here, the case of a 67-year-old patient who underwent several arthroplasty procedures because of osteoarthrosis caused by this rare pathological condition is presented. The last surgical intervention consisted of total right knee arthroplasty.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162014000600675&lng=en&tlng=enAlcaptonúriaOcronoseJoelhoArtroplastia |
| spellingShingle | Andreia Maria da Silva Martins Ferreira Filipe Lima Santos André Miguel Castro Costa Bruno Miguel Pereira Barbosa Rui Miguel Reis Rocha Joaquim Fernando Fontes Lebre Knee osteoarthrosis secondary to ochronosis -clinical case, Revista Brasileira de Ortopedia Alcaptonúria Ocronose Joelho Artroplastia |
| title | Knee osteoarthrosis secondary to ochronosis -clinical case, |
| title_full | Knee osteoarthrosis secondary to ochronosis -clinical case, |
| title_fullStr | Knee osteoarthrosis secondary to ochronosis -clinical case, |
| title_full_unstemmed | Knee osteoarthrosis secondary to ochronosis -clinical case, |
| title_short | Knee osteoarthrosis secondary to ochronosis -clinical case, |
| title_sort | knee osteoarthrosis secondary to ochronosis clinical case |
| topic | Alcaptonúria Ocronose Joelho Artroplastia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162014000600675&lng=en&tlng=en |
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