Inflammatory Cytokines in Diabetic Kidney Disease: Pathophysiologic and Therapeutic Implications
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease and a main contributing factor for cardiovascular morbidity and mortality in patients with diabetes mellitus. Strategies employed to delay the progression of this pathology focus on the control of traditional risk factors,...
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| Format: | Article |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2020.628289/full |
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| author | Javier Donate-Correa Javier Donate-Correa Carla M. Ferri Carla M. Ferri Fátima Sánchez-Quintana Fátima Sánchez-Quintana Atteneri Pérez-Castro Ainhoa González-Luis Ernesto Martín-Núñez Ernesto Martín-Núñez Ernesto Martín-Núñez Carmen Mora-Fernández Juan F. Navarro-González Juan F. Navarro-González Juan F. Navarro-González Juan F. Navarro-González |
| author_facet | Javier Donate-Correa Javier Donate-Correa Carla M. Ferri Carla M. Ferri Fátima Sánchez-Quintana Fátima Sánchez-Quintana Atteneri Pérez-Castro Ainhoa González-Luis Ernesto Martín-Núñez Ernesto Martín-Núñez Ernesto Martín-Núñez Carmen Mora-Fernández Juan F. Navarro-González Juan F. Navarro-González Juan F. Navarro-González Juan F. Navarro-González |
| author_sort | Javier Donate-Correa |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease and a main contributing factor for cardiovascular morbidity and mortality in patients with diabetes mellitus. Strategies employed to delay the progression of this pathology focus on the control of traditional risk factors, such as hyperglycemia, and elevated blood pressure. Although the intimate mechanisms involved in the onset and progression of DKD remain incompletely understood, inflammation is currently recognized as one of the main underlying processes. Untangling the mechanisms involved in the appearing of a harmful inflammatory response in the diabetic patient is crucial for the development of new therapeutic strategies. In this review, we focus on the inflammation-related pathogenic mechanisms involved in DKD and in the therapeutic utility of new anti-inflammatory strategies. |
| first_indexed | 2024-12-14T01:03:25Z |
| format | Article |
| id | doaj.art-dc245bdb4e154cde8fc147d5709e1f25 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-14T01:03:25Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-dc245bdb4e154cde8fc147d5709e1f252022-12-21T23:23:07ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-01-01710.3389/fmed.2020.628289628289Inflammatory Cytokines in Diabetic Kidney Disease: Pathophysiologic and Therapeutic ImplicationsJavier Donate-Correa0Javier Donate-Correa1Carla M. Ferri2Carla M. Ferri3Fátima Sánchez-Quintana4Fátima Sánchez-Quintana5Atteneri Pérez-Castro6Ainhoa González-Luis7Ernesto Martín-Núñez8Ernesto Martín-Núñez9Ernesto Martín-Núñez10Carmen Mora-Fernández11Juan F. Navarro-González12Juan F. Navarro-González13Juan F. Navarro-González14Juan F. Navarro-González15Unidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, SpainGEENDIAB (Grupo Español para el Estudio de la Nefropatía Diabética), Sociedad Española de Nefrología, Santander, SpainUnidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, SpainDoctoral and Graduate School, University of La Laguna, San Cristóbal de La Laguna, SpainUnidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, SpainDoctoral and Graduate School, University of La Laguna, San Cristóbal de La Laguna, SpainUnidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, SpainUnidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, SpainUnidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, SpainGEENDIAB (Grupo Español para el Estudio de la Nefropatía Diabética), Sociedad Española de Nefrología, Santander, SpainDoctoral and Graduate School, University of La Laguna, San Cristóbal de La Laguna, SpainUnidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, SpainUnidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, SpainGEENDIAB (Grupo Español para el Estudio de la Nefropatía Diabética), Sociedad Española de Nefrología, Santander, SpainREDINREN (Red de Investigación Renal-RD16/0009/0022), Instituto de Salud Carlos III, Madrid, SpainInstituto de Tecnologías Biomédicas, Universidad de La Laguna, Santa Cruz de Tenerife, SpainDiabetic kidney disease (DKD) is the leading cause of end-stage renal disease and a main contributing factor for cardiovascular morbidity and mortality in patients with diabetes mellitus. Strategies employed to delay the progression of this pathology focus on the control of traditional risk factors, such as hyperglycemia, and elevated blood pressure. Although the intimate mechanisms involved in the onset and progression of DKD remain incompletely understood, inflammation is currently recognized as one of the main underlying processes. Untangling the mechanisms involved in the appearing of a harmful inflammatory response in the diabetic patient is crucial for the development of new therapeutic strategies. In this review, we focus on the inflammation-related pathogenic mechanisms involved in DKD and in the therapeutic utility of new anti-inflammatory strategies.https://www.frontiersin.org/articles/10.3389/fmed.2020.628289/fulldiabetic kidney diseaseinflammationinflammatory cytokinesSGLT2iGLP-1RADPP-4i |
| spellingShingle | Javier Donate-Correa Javier Donate-Correa Carla M. Ferri Carla M. Ferri Fátima Sánchez-Quintana Fátima Sánchez-Quintana Atteneri Pérez-Castro Ainhoa González-Luis Ernesto Martín-Núñez Ernesto Martín-Núñez Ernesto Martín-Núñez Carmen Mora-Fernández Juan F. Navarro-González Juan F. Navarro-González Juan F. Navarro-González Juan F. Navarro-González Inflammatory Cytokines in Diabetic Kidney Disease: Pathophysiologic and Therapeutic Implications Frontiers in Medicine diabetic kidney disease inflammation inflammatory cytokines SGLT2i GLP-1RA DPP-4i |
| title | Inflammatory Cytokines in Diabetic Kidney Disease: Pathophysiologic and Therapeutic Implications |
| title_full | Inflammatory Cytokines in Diabetic Kidney Disease: Pathophysiologic and Therapeutic Implications |
| title_fullStr | Inflammatory Cytokines in Diabetic Kidney Disease: Pathophysiologic and Therapeutic Implications |
| title_full_unstemmed | Inflammatory Cytokines in Diabetic Kidney Disease: Pathophysiologic and Therapeutic Implications |
| title_short | Inflammatory Cytokines in Diabetic Kidney Disease: Pathophysiologic and Therapeutic Implications |
| title_sort | inflammatory cytokines in diabetic kidney disease pathophysiologic and therapeutic implications |
| topic | diabetic kidney disease inflammation inflammatory cytokines SGLT2i GLP-1RA DPP-4i |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2020.628289/full |
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