A comparative study of cytomorphological features of primary and metastatic hepatic lesions - A tertiary care hospital experience
Background: Ultrasonography (USG)-guided fine-needle aspiration cytology (FNAC) of the liver is a primary diagnostic procedure for primary and metastatic hepatic lesions. It is a minimally invasive and accurate technique and renders timely diagnosis for further management. Aims and Objectives: Th...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-10-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/54873 |
| _version_ | 1797665905894752256 |
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| author | Sujitha R Mohamed Hamza A Kandibanda Sai Sri Ram Rao Vashista Sai Kumar G |
| author_facet | Sujitha R Mohamed Hamza A Kandibanda Sai Sri Ram Rao Vashista Sai Kumar G |
| author_sort | Sujitha R |
| collection | DOAJ |
| description | Background: Ultrasonography (USG)-guided fine-needle aspiration cytology (FNAC) of the liver is a primary diagnostic procedure for primary and metastatic hepatic lesions. It is a minimally invasive and accurate technique and renders timely diagnosis for further management.
Aims and Objectives: The purpose of the study was to evaluate the cytomorphological features of primary and metastatic hepatic lesions.
Materials and Methods: This retrospective study was conducted in the Department of Pathology of a tertiary care hospital over a period of 2 years. 50 cases of clinically suspicious cases for hepatic malignancy were radiologically confirmed by USG and were subjected to FNAC under USG guidance with simultaneous cell block preparation in 35 cases. Relevant biochemical and serological data were retrieved from laboratory investigation archives.
Results: The study was conducted on 50 cases of hepatic lesion. Majority of cases were male patients. All liver lesions were diagnosed on USG scan. Out of 50 cases diagnosed cytomorphologically, 8 cases (16%) were diagnosed as hepatocellular carcinoma. Among metastatic lesions, more prevalent lesions were adenocarcinoma 20 (40%). The rest of metastatic deposits included poorly differentiated carcinoma 12 (24%), mucinous carcinoma 4 (8%), malignant lymphoma 3 (6%), neuroendocrine tumor 2 (4%), and malignant melanoma 1 (2%). Primary site for metastatic lesions was diagnosed in 22 cases (52.4%) and unknown in 20 cases (47.6%).
Conclusion: FNAC is a quick, feasible, and reliable procedure which enables the interpretation of cytological features of malignant hepatic masses. |
| first_indexed | 2024-03-11T19:50:49Z |
| format | Article |
| id | doaj.art-dc2484f80d4141229ebe040de4e1c15e |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-11T19:50:49Z |
| publishDate | 2023-10-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-dc2484f80d4141229ebe040de4e1c15e2023-10-05T10:12:03ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-10-011410286291https://doi.org/10.3126/ajms.v14i10.54873A comparative study of cytomorphological features of primary and metastatic hepatic lesions - A tertiary care hospital experienceSujitha R 0https://orcid.org/0009-0003-4780-7776Mohamed Hamza A 1https://orcid.org/0009-0001-0235-6479Kandibanda Sai Sri Ram Rao 2https://orcid.org/0009-0002-4408-9281Vashista Sai Kumar G 3https://orcid.org/0009-0002-7234-1261Assistant Professor, Department of Pathology, MVJ Medical College and Research Hospital, Bengaluru, Karnataka, India Assistant Professor, Department of Pathology, MVJ Medical College and Research Hospital, Bengaluru, Karnataka, India Fellow in Center for Oncopathology, Mumbai, Maharashtra, India Assistant Professor, Department of Pathology, MVJ Medical College and Research Hospital, Bengaluru, Karnataka, India Background: Ultrasonography (USG)-guided fine-needle aspiration cytology (FNAC) of the liver is a primary diagnostic procedure for primary and metastatic hepatic lesions. It is a minimally invasive and accurate technique and renders timely diagnosis for further management. Aims and Objectives: The purpose of the study was to evaluate the cytomorphological features of primary and metastatic hepatic lesions. Materials and Methods: This retrospective study was conducted in the Department of Pathology of a tertiary care hospital over a period of 2 years. 50 cases of clinically suspicious cases for hepatic malignancy were radiologically confirmed by USG and were subjected to FNAC under USG guidance with simultaneous cell block preparation in 35 cases. Relevant biochemical and serological data were retrieved from laboratory investigation archives. Results: The study was conducted on 50 cases of hepatic lesion. Majority of cases were male patients. All liver lesions were diagnosed on USG scan. Out of 50 cases diagnosed cytomorphologically, 8 cases (16%) were diagnosed as hepatocellular carcinoma. Among metastatic lesions, more prevalent lesions were adenocarcinoma 20 (40%). The rest of metastatic deposits included poorly differentiated carcinoma 12 (24%), mucinous carcinoma 4 (8%), malignant lymphoma 3 (6%), neuroendocrine tumor 2 (4%), and malignant melanoma 1 (2%). Primary site for metastatic lesions was diagnosed in 22 cases (52.4%) and unknown in 20 cases (47.6%). Conclusion: FNAC is a quick, feasible, and reliable procedure which enables the interpretation of cytological features of malignant hepatic masses.https://www.nepjol.info/index.php/AJMS/article/view/54873fine-needle aspiration cytology; hepatic masses; cytomorphology |
| spellingShingle | Sujitha R Mohamed Hamza A Kandibanda Sai Sri Ram Rao Vashista Sai Kumar G A comparative study of cytomorphological features of primary and metastatic hepatic lesions - A tertiary care hospital experience Asian Journal of Medical Sciences fine-needle aspiration cytology; hepatic masses; cytomorphology |
| title | A comparative study of cytomorphological features of primary and metastatic hepatic lesions - A tertiary care hospital experience |
| title_full | A comparative study of cytomorphological features of primary and metastatic hepatic lesions - A tertiary care hospital experience |
| title_fullStr | A comparative study of cytomorphological features of primary and metastatic hepatic lesions - A tertiary care hospital experience |
| title_full_unstemmed | A comparative study of cytomorphological features of primary and metastatic hepatic lesions - A tertiary care hospital experience |
| title_short | A comparative study of cytomorphological features of primary and metastatic hepatic lesions - A tertiary care hospital experience |
| title_sort | comparative study of cytomorphological features of primary and metastatic hepatic lesions a tertiary care hospital experience |
| topic | fine-needle aspiration cytology; hepatic masses; cytomorphology |
| url | https://www.nepjol.info/index.php/AJMS/article/view/54873 |
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