Gene × Gene interaction between <it>MnSOD </it>and <it>GPX-1 </it>and breast cancer risk: a nested case-control study
<p>Abstract</p> <p>Background</p> <p>Germ-line mutations in genes such as <it>BRCA1</it>, <it>BRCA2</it>, and <it>ATM </it>can cause a substantial increase in risk of breast cancer. However, these mutations are rare in the general pop...
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| Format: | Article |
| Language: | English |
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BMC
2006-08-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/6/217 |
| _version_ | 1811266068724842496 |
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| author | Tamimi Rulla M Cox David G Hunter David J |
| author_facet | Tamimi Rulla M Cox David G Hunter David J |
| author_sort | Tamimi Rulla M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Germ-line mutations in genes such as <it>BRCA1</it>, <it>BRCA2</it>, and <it>ATM </it>can cause a substantial increase in risk of breast cancer. However, these mutations are rare in the general population, and account for little of the incidence of sporadic breast cancer in the general population. Therefore, research has been focused on examining associations between common polymorphisms and breast cancer risk. To date, few associations have been described. This has led to the hypothesis that breast cancer is a complex disease, whereby a constellation of very low penetrance alleles need to be carried to present a risk phenotype. Polymorphisms in the manganese superoxide dismutase (<it>MnSOD</it>) and glutathione peroxidase (<it>GPX-1</it>) genes have been proposed as low penetrance alleles, and have not been clearly associated with breast cancer. We investigated whether variants at both polymorphisms, while not independently associated with breast cancer risk, could influence breast cancer risk when considered together.</p> <p>Methods</p> <p>A case-control study nested within the Nurses' Health Study was performed comparing 1262 women diagnosed with breast cancer to 1533 disease free women. The <it>MnSOD </it>(Val16Ala, rs1799725) and <it>GPX-1 </it>(Pro198Leu, rs1050450) were genotyped via TaqMan assay. Disease risk was evaluated using logistic regression.</p> <p>Results</p> <p>While neither allele alone shows any change in breast cancer risk, an increase in the risk of breast cancer (OR 1.87, 95% CI 1.09 – 3.19) is observed in individuals who carry both the Ala16Ala genotype of <it>MnSOD </it>and the Leu198Leu genotype of <it>GPX-1</it>.</p> <p>Conclusion</p> <p>Polymorphisms in the <it>GPX-1 </it>and <it>MnSOD </it>genes are associated with an increased risk of breast cancer.</p> |
| first_indexed | 2024-04-12T20:35:25Z |
| format | Article |
| id | doaj.art-dc27692f100a401d8915f4b759145106 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-12T20:35:25Z |
| publishDate | 2006-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-dc27692f100a401d8915f4b7591451062022-12-22T03:17:36ZengBMCBMC Cancer1471-24072006-08-016121710.1186/1471-2407-6-217Gene × Gene interaction between <it>MnSOD </it>and <it>GPX-1 </it>and breast cancer risk: a nested case-control studyTamimi Rulla MCox David GHunter David J<p>Abstract</p> <p>Background</p> <p>Germ-line mutations in genes such as <it>BRCA1</it>, <it>BRCA2</it>, and <it>ATM </it>can cause a substantial increase in risk of breast cancer. However, these mutations are rare in the general population, and account for little of the incidence of sporadic breast cancer in the general population. Therefore, research has been focused on examining associations between common polymorphisms and breast cancer risk. To date, few associations have been described. This has led to the hypothesis that breast cancer is a complex disease, whereby a constellation of very low penetrance alleles need to be carried to present a risk phenotype. Polymorphisms in the manganese superoxide dismutase (<it>MnSOD</it>) and glutathione peroxidase (<it>GPX-1</it>) genes have been proposed as low penetrance alleles, and have not been clearly associated with breast cancer. We investigated whether variants at both polymorphisms, while not independently associated with breast cancer risk, could influence breast cancer risk when considered together.</p> <p>Methods</p> <p>A case-control study nested within the Nurses' Health Study was performed comparing 1262 women diagnosed with breast cancer to 1533 disease free women. The <it>MnSOD </it>(Val16Ala, rs1799725) and <it>GPX-1 </it>(Pro198Leu, rs1050450) were genotyped via TaqMan assay. Disease risk was evaluated using logistic regression.</p> <p>Results</p> <p>While neither allele alone shows any change in breast cancer risk, an increase in the risk of breast cancer (OR 1.87, 95% CI 1.09 – 3.19) is observed in individuals who carry both the Ala16Ala genotype of <it>MnSOD </it>and the Leu198Leu genotype of <it>GPX-1</it>.</p> <p>Conclusion</p> <p>Polymorphisms in the <it>GPX-1 </it>and <it>MnSOD </it>genes are associated with an increased risk of breast cancer.</p>http://www.biomedcentral.com/1471-2407/6/217 |
| spellingShingle | Tamimi Rulla M Cox David G Hunter David J Gene × Gene interaction between <it>MnSOD </it>and <it>GPX-1 </it>and breast cancer risk: a nested case-control study BMC Cancer |
| title | Gene × Gene interaction between <it>MnSOD </it>and <it>GPX-1 </it>and breast cancer risk: a nested case-control study |
| title_full | Gene × Gene interaction between <it>MnSOD </it>and <it>GPX-1 </it>and breast cancer risk: a nested case-control study |
| title_fullStr | Gene × Gene interaction between <it>MnSOD </it>and <it>GPX-1 </it>and breast cancer risk: a nested case-control study |
| title_full_unstemmed | Gene × Gene interaction between <it>MnSOD </it>and <it>GPX-1 </it>and breast cancer risk: a nested case-control study |
| title_short | Gene × Gene interaction between <it>MnSOD </it>and <it>GPX-1 </it>and breast cancer risk: a nested case-control study |
| title_sort | gene gene interaction between it mnsod it and it gpx 1 it and breast cancer risk a nested case control study |
| url | http://www.biomedcentral.com/1471-2407/6/217 |
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