Radiofrequency Ablation of Hepatocellular Carcinomas Adjacent to the Gallbladder Without Isolation Under Contrast-Enhanced Ultrasound Monitoring: A Comparative Study with Long Term Follow-Up
Liping Luo,1,2,* Ronghua Yan,3,4,* Qingjing Zeng,2 Yinglin Long,2 Xuqi He,2 Kai Li,2 Erjiao Xu1 1Department of Medical Ultrasonics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, People’s Republic of China; 2Department of Medical Ultrasonics, The Third Affiliated...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-04-01
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| Series: | Journal of Hepatocellular Carcinoma |
| Subjects: | |
| Online Access: | https://www.dovepress.com/radiofrequency-ablation-of-hepatocellular-carcinomas-adjacent-to-the-g-peer-reviewed-fulltext-article-JHC |
| _version_ | 1797847390990893056 |
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| author | Luo L Yan R Zeng Q Long Y He X Li K Xu E |
| author_facet | Luo L Yan R Zeng Q Long Y He X Li K Xu E |
| author_sort | Luo L |
| collection | DOAJ |
| description | Liping Luo,1,2,* Ronghua Yan,3,4,* Qingjing Zeng,2 Yinglin Long,2 Xuqi He,2 Kai Li,2 Erjiao Xu1 1Department of Medical Ultrasonics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, People’s Republic of China; 2Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China; 3Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, People’s Republic of China; 4Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Erjiao Xu, Department of Medical Ultrasonics, The Eighth Affiliated Hospital of Sun Yat-sen University, No. 3025, Shennanzhong Road, Shenzhen, 518033, People’s Republic of China, Email xuerjiao@mail.sysu.edu.cn Kai Li, Department of Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People’s Republic of China, Email likai@mail.sysu.edu.cnObjective: This study intends to compare the efficacy and safety between patients undergoing invasive isolation or monitoring measures and patients undergoing intra-operative contrast-enhanced ultrasound (CEUS) monitoring who underwent radiofrequency ablation (RFA) of hepatocellular carcinomas (HCC) adjacent to the gallbladder (GB).Methods: We retrospectively assessed patients with HCC adjacent to the GB who underwent ultrasound-guided RFA. They were divided into two groups: group A was monitored under intra-operative CEUS, while group B was assisted by invasive auxiliary means. The efficacy, complications and survival were followed up and compared.Results: Thirty-eight patients with 39 HCCs were enrolled into group A and 31 patients with 35 HCCs were enrolled into group B. The technique efficacy rates were both 100% in the two groups. There were no significant differences of the cumulative 1-, 3-, and 5-year local tumor progression, tumor-free survival and overall survival between the two groups (P = 0.851, 0.081 and 0.700, respectively). There were no significant differences of major and minor complications rates between the two groups (P = 1.000, 0.994, respectively). More importantly, no GB related complications occurred in group A.Conclusion: Intra-operative CEUS monitoring without protective isolation of the GB might be also a potentially safe and effective method for the RFA of HCC adjacent to the GB, when compared with those assisted with invasive auxiliary means.Keywords: hepatocellular carcinoma, gallbladder, contrast-enhanced ultrasound, thermal ablation, monitoring |
| first_indexed | 2024-04-09T18:11:45Z |
| format | Article |
| id | doaj.art-dc297967a64242dcb260ace4c3637514 |
| institution | Directory Open Access Journal |
| issn | 2253-5969 |
| language | English |
| last_indexed | 2024-04-09T18:11:45Z |
| publishDate | 2023-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Hepatocellular Carcinoma |
| spelling | doaj.art-dc297967a64242dcb260ace4c36375142023-04-13T19:17:09ZengDove Medical PressJournal of Hepatocellular Carcinoma2253-59692023-04-01Volume 1063164283006Radiofrequency Ablation of Hepatocellular Carcinomas Adjacent to the Gallbladder Without Isolation Under Contrast-Enhanced Ultrasound Monitoring: A Comparative Study with Long Term Follow-UpLuo LYan RZeng QLong YHe XLi KXu ELiping Luo,1,2,* Ronghua Yan,3,4,* Qingjing Zeng,2 Yinglin Long,2 Xuqi He,2 Kai Li,2 Erjiao Xu1 1Department of Medical Ultrasonics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, People’s Republic of China; 2Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China; 3Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, People’s Republic of China; 4Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Erjiao Xu, Department of Medical Ultrasonics, The Eighth Affiliated Hospital of Sun Yat-sen University, No. 3025, Shennanzhong Road, Shenzhen, 518033, People’s Republic of China, Email xuerjiao@mail.sysu.edu.cn Kai Li, Department of Ultrasound, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People’s Republic of China, Email likai@mail.sysu.edu.cnObjective: This study intends to compare the efficacy and safety between patients undergoing invasive isolation or monitoring measures and patients undergoing intra-operative contrast-enhanced ultrasound (CEUS) monitoring who underwent radiofrequency ablation (RFA) of hepatocellular carcinomas (HCC) adjacent to the gallbladder (GB).Methods: We retrospectively assessed patients with HCC adjacent to the GB who underwent ultrasound-guided RFA. They were divided into two groups: group A was monitored under intra-operative CEUS, while group B was assisted by invasive auxiliary means. The efficacy, complications and survival were followed up and compared.Results: Thirty-eight patients with 39 HCCs were enrolled into group A and 31 patients with 35 HCCs were enrolled into group B. The technique efficacy rates were both 100% in the two groups. There were no significant differences of the cumulative 1-, 3-, and 5-year local tumor progression, tumor-free survival and overall survival between the two groups (P = 0.851, 0.081 and 0.700, respectively). There were no significant differences of major and minor complications rates between the two groups (P = 1.000, 0.994, respectively). More importantly, no GB related complications occurred in group A.Conclusion: Intra-operative CEUS monitoring without protective isolation of the GB might be also a potentially safe and effective method for the RFA of HCC adjacent to the GB, when compared with those assisted with invasive auxiliary means.Keywords: hepatocellular carcinoma, gallbladder, contrast-enhanced ultrasound, thermal ablation, monitoringhttps://www.dovepress.com/radiofrequency-ablation-of-hepatocellular-carcinomas-adjacent-to-the-g-peer-reviewed-fulltext-article-JHChepatocellular carcinomagallbladdercontrast-enhanced ultrasoundthermal ablationmonitoring |
| spellingShingle | Luo L Yan R Zeng Q Long Y He X Li K Xu E Radiofrequency Ablation of Hepatocellular Carcinomas Adjacent to the Gallbladder Without Isolation Under Contrast-Enhanced Ultrasound Monitoring: A Comparative Study with Long Term Follow-Up Journal of Hepatocellular Carcinoma hepatocellular carcinoma gallbladder contrast-enhanced ultrasound thermal ablation monitoring |
| title | Radiofrequency Ablation of Hepatocellular Carcinomas Adjacent to the Gallbladder Without Isolation Under Contrast-Enhanced Ultrasound Monitoring: A Comparative Study with Long Term Follow-Up |
| title_full | Radiofrequency Ablation of Hepatocellular Carcinomas Adjacent to the Gallbladder Without Isolation Under Contrast-Enhanced Ultrasound Monitoring: A Comparative Study with Long Term Follow-Up |
| title_fullStr | Radiofrequency Ablation of Hepatocellular Carcinomas Adjacent to the Gallbladder Without Isolation Under Contrast-Enhanced Ultrasound Monitoring: A Comparative Study with Long Term Follow-Up |
| title_full_unstemmed | Radiofrequency Ablation of Hepatocellular Carcinomas Adjacent to the Gallbladder Without Isolation Under Contrast-Enhanced Ultrasound Monitoring: A Comparative Study with Long Term Follow-Up |
| title_short | Radiofrequency Ablation of Hepatocellular Carcinomas Adjacent to the Gallbladder Without Isolation Under Contrast-Enhanced Ultrasound Monitoring: A Comparative Study with Long Term Follow-Up |
| title_sort | radiofrequency ablation of hepatocellular carcinomas adjacent to the gallbladder without isolation under contrast enhanced ultrasound monitoring a comparative study with long term follow up |
| topic | hepatocellular carcinoma gallbladder contrast-enhanced ultrasound thermal ablation monitoring |
| url | https://www.dovepress.com/radiofrequency-ablation-of-hepatocellular-carcinomas-adjacent-to-the-g-peer-reviewed-fulltext-article-JHC |
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