Cortical thickness is related to working memory performance after non-invasive brain stimulation
Non-invasive brain stimulation (NIBS) probing the dorsolateral prefrontal cortex (DLPFC) has been shown to have little effect on working memory. The variability of NIBS responses might be explained by inter-subject brain anatomical variability. We investigated whether baseline cortical brain thickne...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2023-10-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100675&tlng=en |
| _version_ | 1797652485237637120 |
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| author | L.B. Razza M.A. Vanderhasselt M.S. Luethi J. Repple G. Busatto C.A. Buchpiguel A.R. Brunoni P.H.R. da Silva |
| author_facet | L.B. Razza M.A. Vanderhasselt M.S. Luethi J. Repple G. Busatto C.A. Buchpiguel A.R. Brunoni P.H.R. da Silva |
| author_sort | L.B. Razza |
| collection | DOAJ |
| description | Non-invasive brain stimulation (NIBS) probing the dorsolateral prefrontal cortex (DLPFC) has been shown to have little effect on working memory. The variability of NIBS responses might be explained by inter-subject brain anatomical variability. We investigated whether baseline cortical brain thickness of regions of interest was associated with working memory performance after NIBS by performing a secondary analysis of previously published research. Structural magnetic resonance imaging data were analyzed from healthy subjects who received transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), and placebo. Twenty-two participants were randomly assigned to receive all the interventions in a random order. The working memory task was conducted after the end of each NIBS session. Regions of interest were the bilateral DLPFC, medial prefrontal cortex, and posterior cingulate cortex. Overall, 66 NIBS sessions were performed. Findings revealed a negative significant association between cortical thickness of the bilateral dorsolateral prefrontal cortex and reaction time for both tDCS (left: P=0.045, right: P=0.037) and iTBS (left: P=0.007, right: P=0.007) compared to placebo. A significant positive association was found for iTBS and posterior cingulate cortex (P=0.03). No association was found for accuracy. Our findings provide the first evidence that individual cortical thickness of healthy subjects might be associated with working memory performance following different NIBS interventions. Therefore, cortical thickness could explain - to some extent - the heterogeneous effects of NIBS probing the DLPFC. |
| first_indexed | 2024-03-11T16:30:36Z |
| format | Article |
| id | doaj.art-dc29fe5745ae480a8b7c41a44c6b7b38 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-03-11T16:30:36Z |
| publishDate | 2023-10-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-dc29fe5745ae480a8b7c41a44c6b7b382023-10-24T07:38:17ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2023-10-015610.1590/1414-431x2023e12945Cortical thickness is related to working memory performance after non-invasive brain stimulationL.B. Razzahttps://orcid.org/0000-0002-0071-0921M.A. Vanderhasselthttps://orcid.org/0000-0002-4045-1055M.S. Luethihttps://orcid.org/0000-0002-2609-0679J. Repplehttps://orcid.org/0000-0003-1379-9491G. Busattohttps://orcid.org/0000-0003-4749-4602C.A. Buchpiguelhttps://orcid.org/0000-0003-0956-2790A.R. Brunonihttps://orcid.org/0000-0002-6310-3571P.H.R. da Silvahttps://orcid.org/0000-0002-0230-7474Non-invasive brain stimulation (NIBS) probing the dorsolateral prefrontal cortex (DLPFC) has been shown to have little effect on working memory. The variability of NIBS responses might be explained by inter-subject brain anatomical variability. We investigated whether baseline cortical brain thickness of regions of interest was associated with working memory performance after NIBS by performing a secondary analysis of previously published research. Structural magnetic resonance imaging data were analyzed from healthy subjects who received transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), and placebo. Twenty-two participants were randomly assigned to receive all the interventions in a random order. The working memory task was conducted after the end of each NIBS session. Regions of interest were the bilateral DLPFC, medial prefrontal cortex, and posterior cingulate cortex. Overall, 66 NIBS sessions were performed. Findings revealed a negative significant association between cortical thickness of the bilateral dorsolateral prefrontal cortex and reaction time for both tDCS (left: P=0.045, right: P=0.037) and iTBS (left: P=0.007, right: P=0.007) compared to placebo. A significant positive association was found for iTBS and posterior cingulate cortex (P=0.03). No association was found for accuracy. Our findings provide the first evidence that individual cortical thickness of healthy subjects might be associated with working memory performance following different NIBS interventions. Therefore, cortical thickness could explain - to some extent - the heterogeneous effects of NIBS probing the DLPFC.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100675&tlng=enNon-invasive brain stimulationCortical thicknessIndividualizationWorking memoryVoxel-based morphometry |
| spellingShingle | L.B. Razza M.A. Vanderhasselt M.S. Luethi J. Repple G. Busatto C.A. Buchpiguel A.R. Brunoni P.H.R. da Silva Cortical thickness is related to working memory performance after non-invasive brain stimulation Brazilian Journal of Medical and Biological Research Non-invasive brain stimulation Cortical thickness Individualization Working memory Voxel-based morphometry |
| title | Cortical thickness is related to working memory performance after non-invasive brain stimulation |
| title_full | Cortical thickness is related to working memory performance after non-invasive brain stimulation |
| title_fullStr | Cortical thickness is related to working memory performance after non-invasive brain stimulation |
| title_full_unstemmed | Cortical thickness is related to working memory performance after non-invasive brain stimulation |
| title_short | Cortical thickness is related to working memory performance after non-invasive brain stimulation |
| title_sort | cortical thickness is related to working memory performance after non invasive brain stimulation |
| topic | Non-invasive brain stimulation Cortical thickness Individualization Working memory Voxel-based morphometry |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100675&tlng=en |
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