miR-146a deficiency in hematopoietic cells is not involved in the development of atherosclerosis.

miR-146a deficiency in hematopoietic cells is not involved in the development of atherosclerosis.

BACKGROUND:Atherosclerosis involves activation of the IRAK1/TRAF6/NF-κB inflammatory cascade, which is negatively regulated by miR146a. Previous studies showed that the TT genotype of rs2431697, located near the miR-146a gene, drives lower miR-146a transcription and predicts adverse cardiovascular e...

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Main Authors: Alberto Del Monte, Ana B Arroyo, María J Andrés-Manzano, Nuria García-Barberá, María S Caleprico, Vicente Vicente, Vanessa Roldán, Rocío González-Conejero, Constantino Martínez, Vicente Andrés
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6002112?pdf=render

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