Levodopa-induced dyskinesia is associated with increased thyrotropin releasing hormone in the dorsal striatum of hemi-parkinsonian rats.

Levodopa-induced dyskinesia is associated with increased thyrotropin releasing hormone in the dorsal striatum of hemi-parkinsonian rats.

Dyskinesias associated with involuntary movements and painful muscle contractions are a common and severe complication of standard levodopa (L-DOPA, L-3,4-dihydroxyphenylalanine) therapy for Parkinson's disease. Pathologic neuroplasticity leading to hyper-responsive dopamine receptor signaling...

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Bibliographic Details
Main Authors: Ippolita Cantuti-Castelvetri, Ledia F Hernandez, Christine E Keller-McGandy, Lauren R Kett, Alex Landy, Zane R Hollingsworth, Esen Saka, Jill R Crittenden, Eduardo A Nillni, Anne B Young, David G Standaert, Ann M Graybiel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2978093?pdf=render

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