Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family
Bacterial pathogens are able to survive within diverse habitats. The dynamic adaptation to the surroundings depends on their ability to sense environmental variations and to respond in an appropriate manner. This involves, among others, the activation of various cell-to-cell communication strategies...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.723274/full |
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| author | Martina Pasqua Maria Carmela Bonaccorsi di Patti Giulia Fanelli Ryutaro Utsumi Yoko Eguchi Rita Trirocco Gianni Prosseda Milena Grossi Bianca Colonna |
| author_facet | Martina Pasqua Maria Carmela Bonaccorsi di Patti Giulia Fanelli Ryutaro Utsumi Yoko Eguchi Rita Trirocco Gianni Prosseda Milena Grossi Bianca Colonna |
| author_sort | Martina Pasqua |
| collection | DOAJ |
| description | Bacterial pathogens are able to survive within diverse habitats. The dynamic adaptation to the surroundings depends on their ability to sense environmental variations and to respond in an appropriate manner. This involves, among others, the activation of various cell-to-cell communication strategies. The capability of the bacterial cells to rapidly and co-ordinately set up an interplay with the host cells and/or with other bacteria facilitates their survival in the new niche. Efflux pumps are ubiquitous transmembrane transporters, able to extrude a large set of different molecules. They are strongly implicated in antibiotic resistance since they are able to efficiently expel most of the clinically relevant antibiotics from the bacterial cytoplasm. Besides antibiotic resistance, multidrug efflux pumps take part in several important processes of bacterial cell physiology, including cell to cell communication, and contribute to increase the virulence potential of several bacterial pathogens. Here, we focus on the structural and functional role of multidrug efflux pumps belonging to the Major Facilitator Superfamily (MFS), the largest family of transporters, highlighting their involvement in the colonization of host cells, in virulence and in biofilm formation. We will offer an overview on how MFS multidrug transporters contribute to bacterial survival, adaptation and pathogenicity through the export of diverse molecules. This will be done by presenting the functions of several relevant MFS multidrug efflux pumps in human life-threatening bacterial pathogens as Staphylococcus aureus, Listeria monocytogenes, Klebsiella pneumoniae, Shigella/E. coli, Acinetobacter baumannii. |
| first_indexed | 2024-12-17T03:12:20Z |
| format | Article |
| id | doaj.art-dc2f799a21b446c2899ccb92849ce9c2 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-17T03:12:20Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-dc2f799a21b446c2899ccb92849ce9c22022-12-21T22:05:47ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-07-01810.3389/fmolb.2021.723274723274Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS FamilyMartina Pasqua0Maria Carmela Bonaccorsi di Patti1Giulia Fanelli2Ryutaro Utsumi3Yoko Eguchi4Rita Trirocco5Gianni Prosseda6Milena Grossi7Bianca Colonna8Department of Biology and Biotechnology “C. Darwin”, Istituto Pasteur Italia, Sapienza Università di Roma, Rome, ItalyDepartment of Biochemical Sciences, Sapienza University, Rome, ItalyDepartment of Biology and Biotechnology “C. Darwin”, Istituto Pasteur Italia, Sapienza Università di Roma, Rome, ItalyThe Institute of Scientific and Industrial Research (SANKEN), Osaka University, Osaka, JapanDepartment of Science and Technology on Food Safety, Kindai University, Kinokawa, JapanDepartment of Biology and Biotechnology “C. Darwin”, Istituto Pasteur Italia, Sapienza Università di Roma, Rome, ItalyDepartment of Biology and Biotechnology “C. Darwin”, Istituto Pasteur Italia, Sapienza Università di Roma, Rome, ItalyDepartment of Biology and Biotechnology “C. Darwin”, Istituto Pasteur Italia, Sapienza Università di Roma, Rome, ItalyDepartment of Biology and Biotechnology “C. Darwin”, Istituto Pasteur Italia, Sapienza Università di Roma, Rome, ItalyBacterial pathogens are able to survive within diverse habitats. The dynamic adaptation to the surroundings depends on their ability to sense environmental variations and to respond in an appropriate manner. This involves, among others, the activation of various cell-to-cell communication strategies. The capability of the bacterial cells to rapidly and co-ordinately set up an interplay with the host cells and/or with other bacteria facilitates their survival in the new niche. Efflux pumps are ubiquitous transmembrane transporters, able to extrude a large set of different molecules. They are strongly implicated in antibiotic resistance since they are able to efficiently expel most of the clinically relevant antibiotics from the bacterial cytoplasm. Besides antibiotic resistance, multidrug efflux pumps take part in several important processes of bacterial cell physiology, including cell to cell communication, and contribute to increase the virulence potential of several bacterial pathogens. Here, we focus on the structural and functional role of multidrug efflux pumps belonging to the Major Facilitator Superfamily (MFS), the largest family of transporters, highlighting their involvement in the colonization of host cells, in virulence and in biofilm formation. We will offer an overview on how MFS multidrug transporters contribute to bacterial survival, adaptation and pathogenicity through the export of diverse molecules. This will be done by presenting the functions of several relevant MFS multidrug efflux pumps in human life-threatening bacterial pathogens as Staphylococcus aureus, Listeria monocytogenes, Klebsiella pneumoniae, Shigella/E. coli, Acinetobacter baumannii.https://www.frontiersin.org/articles/10.3389/fmolb.2021.723274/fullefflux pumpsmajor facilitator superfamilybacteria host interactionstwo component systemsbacterial virulence |
| spellingShingle | Martina Pasqua Maria Carmela Bonaccorsi di Patti Giulia Fanelli Ryutaro Utsumi Yoko Eguchi Rita Trirocco Gianni Prosseda Milena Grossi Bianca Colonna Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family Frontiers in Molecular Biosciences efflux pumps major facilitator superfamily bacteria host interactions two component systems bacterial virulence |
| title | Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family |
| title_full | Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family |
| title_fullStr | Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family |
| title_full_unstemmed | Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family |
| title_short | Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family |
| title_sort | host bacterial pathogen communication the wily role of the multidrug efflux pumps of the mfs family |
| topic | efflux pumps major facilitator superfamily bacteria host interactions two component systems bacterial virulence |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.723274/full |
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