γδ T‐cell responses during HIV infection and antiretroviral therapy
Abstract HIV infection is associated with a rapid and sustained inversion of the Vδ1:Vδ2 T‐cell ratio in peripheral blood. Studies of antiretroviral therapy (ART)‐treated cohorts suggest that ART is insufficient to reconstitute either the frequency or function of the γδ T‐cell subset. Recent advance...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Clinical & Translational Immunology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cti2.1069 |
| _version_ | 1818391021837352960 |
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| author | Jennifer A Juno Emily M Eriksson |
| author_facet | Jennifer A Juno Emily M Eriksson |
| author_sort | Jennifer A Juno |
| collection | DOAJ |
| description | Abstract HIV infection is associated with a rapid and sustained inversion of the Vδ1:Vδ2 T‐cell ratio in peripheral blood. Studies of antiretroviral therapy (ART)‐treated cohorts suggest that ART is insufficient to reconstitute either the frequency or function of the γδ T‐cell subset. Recent advances are now beginning to shed light on the relationship between microbial translocation, chronic inflammation, immune ageing and γδ T‐cell immunology. Here, we review the impact of acute, chronic untreated and treated HIV infection on circulating and mucosal γδ T‐cell subsets and highlight novel approaches to harness γδ T cells as components of anti‐HIV immunotherapy. |
| first_indexed | 2024-12-14T05:06:54Z |
| format | Article |
| id | doaj.art-dc30bfd4ffc84f3eb56e4208265ca5ee |
| institution | Directory Open Access Journal |
| issn | 2050-0068 |
| language | English |
| last_indexed | 2024-12-14T05:06:54Z |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical & Translational Immunology |
| spelling | doaj.art-dc30bfd4ffc84f3eb56e4208265ca5ee2022-12-21T23:16:05ZengWileyClinical & Translational Immunology2050-00682019-01-0187n/an/a10.1002/cti2.1069γδ T‐cell responses during HIV infection and antiretroviral therapyJennifer A Juno0Emily M Eriksson1Department of Microbiology and Immunology The University of Melbourne at The Peter Doherty Institute for Infection and Immunity Melbourne VIC AustraliaDivision of Population Health and Immunity Walter and Eliza Hall Institute of Medical Science Melbourne VIC AustraliaAbstract HIV infection is associated with a rapid and sustained inversion of the Vδ1:Vδ2 T‐cell ratio in peripheral blood. Studies of antiretroviral therapy (ART)‐treated cohorts suggest that ART is insufficient to reconstitute either the frequency or function of the γδ T‐cell subset. Recent advances are now beginning to shed light on the relationship between microbial translocation, chronic inflammation, immune ageing and γδ T‐cell immunology. Here, we review the impact of acute, chronic untreated and treated HIV infection on circulating and mucosal γδ T‐cell subsets and highlight novel approaches to harness γδ T cells as components of anti‐HIV immunotherapy.https://doi.org/10.1002/cti2.1069γδgutHIVSIVVδ1Vδ2 |
| spellingShingle | Jennifer A Juno Emily M Eriksson γδ T‐cell responses during HIV infection and antiretroviral therapy Clinical & Translational Immunology γδ gut HIV SIV Vδ1 Vδ2 |
| title | γδ T‐cell responses during HIV infection and antiretroviral therapy |
| title_full | γδ T‐cell responses during HIV infection and antiretroviral therapy |
| title_fullStr | γδ T‐cell responses during HIV infection and antiretroviral therapy |
| title_full_unstemmed | γδ T‐cell responses during HIV infection and antiretroviral therapy |
| title_short | γδ T‐cell responses during HIV infection and antiretroviral therapy |
| title_sort | γδ t cell responses during hiv infection and antiretroviral therapy |
| topic | γδ gut HIV SIV Vδ1 Vδ2 |
| url | https://doi.org/10.1002/cti2.1069 |
| work_keys_str_mv | AT jenniferajuno gdtcellresponsesduringhivinfectionandantiretroviraltherapy AT emilymeriksson gdtcellresponsesduringhivinfectionandantiretroviraltherapy |